Greater daytime sleepiness in subcortical stroke relative to Parkinson's disease and Alzheimer's disease
Greater daytime sleepiness in subcortical stroke relative to Parkinson's disease and Alzheimer's disease
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DOI：
10.1177/089198870201500202
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发表时间：
2002-06-01
影响因子：
2.6
通讯作者：
Gurecki, P
中科院分区：
文献类型：
--
作者：
Bliwise, DL;Rye, DB;Gurecki, P
老年人白天警觉性的缺陷可能部分反映了调节睡眠和觉醒昼夜节律控制的关键神经系统的退化。在这项研究中，47 名患有皮质下中风 (n = 9)、阿尔茨海默病 (n = 6) 和帕金森病 (n = 32) 的患者接受了 24 小时实验室内评估，包括夜间多导睡眠图和第二天使用多次睡眠潜伏期测试评估日间睡眠倾向。与帕金森病和阿尔茨海默病患者相比，中风患者白天明显更困。夜间睡眠参数并不能解释这些差异。在中风患者中，一些梗塞发生在脉管系统中，影响了下丘脑的血液供应。我们将这些效应解释为代表视交叉上核（SCN）的功能中断。这些结果也与人类视交叉上核的唤醒促进功能相一致。
Deficits in daytime alertness in the elderly may reflect, in part, deterioration of the critical neural systems modulating circadian control of sleep and wakefulness. In this study, 47 patients with subcortical stroke (n = 9), Alzheimer's disease (n = 6), and parkinsonism (n = 32) underwent a 24-hour in-laboratory evaluation consisting of overnight polysomnography and next-day evaluation of daytime sleep tendency with the Multiple Sleep Latency Test. Patients with stroke were significantly sleepier during the daytime relative to the Parkinson's and Alzheimer's disease patients. Nocturnal sleep parameters did not account for these differences. In the stroke patients, some infarcts occurred in the vasculature, impacting blood supply to the hypothalamus. We interpret these effects as representing functional interruptions of the suprachiasmatic nucleus (SCN). These results are also compatible with a wake-promoting function of the human SCN.