Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
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DOI：
10.1016/j.neuroimage.2012.12.014
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发表时间：
2013-04-15
期刊：
影响因子：
5.7
通讯作者：
Hinz, R.
中科院分区：
文献类型：
--
作者：
Edison, P.;Carter, S. F.;Hinz, R.
[C-11][C-11]匹兹堡化合物-B(PIB)是目前应用最广泛的脑淀粉样蛋白正电子发射断层扫描(PET)显像剂。几项评估阿尔茨海默病(AD)进展的纵向研究和许多使用[C-11]PIB PET作为AD生物标记物的治疗干预研究正在进行中。对[C-11]PIB数据的定量分析需要定义感兴趣的区域体积。这项研究系统地比较了两种数据分析方法，这两种方法都使用了包含11个双边区域的概率脑图谱。方法：共54名受试者，20名疑似阿尔茨海默病(AD)患者，14名遗忘性轻度认知障碍(MCI)患者和20名年龄匹配的健康对照，在伦敦(英国)或图尔库(芬兰)的两个成像中心接受扫描。对所有受试者进行结构体积磁共振成像和[C-11]PIB PET扫描。以注射后40分钟和60分钟的靶区与小脑的比率作为结果指标。为这两条路线生成了灰质目标区域的区域读数。基于新皮质、额叶、后扣带回、后扣带回和额叶皮质的复合区域，扫描被归类为“PIB阴性”(PIB-)或“PIB阳性”(PIB+)，分别使用先前报道的1.41、1.5和1.6的截断靶区与小脑的比率。结果：无论诊断如何，当用[C-11]PIB PET模板定义靶区与小脑的比率时，靶区与小脑的比率都大于单独的磁共振成像。这一差异在对照组中非常显著(p
Rationale: [C-11]Pittsburgh compound-B (PIB) has been the most widely used positron emission tomography (PET) imaging agent for brain amyloid. Several longitudinal studies evaluating the progression of Alzheimer's disease (AD), and numerous therapeutic intervention studies are underway using [C-11]PIB PET as an AD bio-marker. Quantitative analysis of [C-11]PIB data requires the definition of regional volumes of interest. This investigation systematically compared two data analysis routes both using a probabilistic brain atlas with 11 bilateral regions. Route 1 used individually segmented structural magnetic resonance images (MRI) for each subject while Route 2 used a standardised [C-11]PIB PET template.Methods: A total of 54 subjects, 20 with probable Alzheimer's disease (AD), 14 with amnestic Mild Cognitive Impairment (MCI) and 20 age-matched healthy controls, were scanned at two imaging centres either in London (UK) or in Turku (Finland). For all subjects structural volumetric MRI and [C-11]PIB PET scans were acquired. Target-to-cerebellum ratios 40 min to 60 min post injection were used as outcome measures. Regional read outs for grey matter target regions were generated for both routes. Based on a composite neocortical, frontal, posterior cingulate, combined posterior cingulate and frontal cortical regions, scans were categorised into either 'PIB negative' (PIB-) or 'PIB positive' (PIB+) using previously reported cut-off target-to-cerebellar ratios of 1.41, 1.5 and 1.6, respectively.Results: Target-to-cerebellum ratios were greater when defined with a [C-11]PIB PET template than with individual MRIs for all cortical regions regardless of diagnosis. This difference was highly significant for controls (p