A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species
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DOI：
10.1111/j.1749-6632.2002.tb04068.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Wink, DA
中科院分区：
文献类型：
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作者：
Espey, MG;Miranda, KM;Wink, DA
一氧化氮（一氧化氮，NO）在正常生理中起着名副其实的调节作用。与此相反，NO还与许多涉及活性氧（ROS）和氮氧化物（RNOS）的神经退行性疾病的病因学和后遗症有关。在这种情况下，NO通常被认为是唯一的致病性;然而，NO的化学性质也可以是减轻ROS和RNOS介导的损伤的重要因素。综述了NO与氧化、亚硝化和硝化反应的关系。突出的因素，确定是否NO促进，减弱，或互连这些化学物质的强调。从NO化学的这个角度来看，ROS或RNOS反应的类型，幅度，位置和持续时间可以预测。
Nitric oxide (nitrogen monoxide, NO) plays a veritable cornucopia of regulatory roles in normal physiology. In contrast, NO has also been implicated in the etiology and sequela of numerous neurodegenerative diseases that involve reactive oxygen species (ROS) and nitrogen oxide species (RNOS). In this setting, NO is often viewed solely as pathogenic; however, the chemistry of NO can also be a significant factor in lessening injury mediated by both ROS and RNOS. The relationship between NO and oxidation, nitrosation, and nitration reactions is summarized. The salient factors that determine whether NO promotes, abates, or interconnects these chemistries are emphasized. From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted.