UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer
UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer
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DOI：
10.1136/thx.2010.152066
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发表时间：
2011-04-01
期刊：
影响因子：
10
通讯作者：
Field, J. K.
中科院分区：
文献类型：
--
作者：
Baldwin, D. R.;Duffy, S. W.;Field, J. K.
英国肺癌筛查（UKLS）是一项使用低剂量多层螺旋CT进行肺癌筛查的随机对照试验。它于2009年10月完成了由卫生技术评估供资的可行性阶段，并将于2011年初启动联合王国学习系统试点。试点将4000名受试者随机分配至低剂量CT筛选或不筛选。完整的研究将于2012年9月开始，如果符合进展标准，将从英国的七个中心随机抽取另外28000名受试者。根据利物浦肺项目风险模型，如果受试者具有足够的肺癌发生风险，则将选择受试者。UKLS采用了“Wald单屏幕设计”，这是UKLS可行性研究的模型。本文介绍了在UKLS结核管理的建模，使用体积分析与一个单一的初始屏幕设计和跟踪期为10年。这种建模导致了UKLS护理途径的开发和采用，该途径将在英国计划的CT筛查试验中实施。
The UK Lung Screen (UKLS) is a randomised controlled trial of the use of low-dose multidetector CT for lung cancer screening. It completed the Health Technology Appraisal (HTA)-funded feasibility stage in October 2009 and the pilot UKLS will be initiated in early 2011. The pilot will randomise 4000 subjects to either low-dose CT screening or no screening. The full study, due to start in September 2012, if progression criteria are met, will randomise a further 28 000 subjects from seven centres in the UK. Subjects will be selected if they have sufficient risk of developing lung cancer according to the Liverpool Lung Project risk model. The UKLS employs the 'Wald Single Screen Design', which was modelled in the UKLS feasibility study. This paper describes the modelling of nodule management in UKLS by using volumetric analysis with a single initial screen design and follow-up period of 10 years. This modelling has resulted in the development and adoption of the UKLS care pathway, which will be implemented in the planned CT screening trial in the UK.