Studies of the natural history and prevention of rubella.
Studies of the natural history and prevention of rubella.
复制标题
风疹自然史和预防的研究。
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
G. S. Mirick
中科院分区：
文献类型：
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作者：
R. Green;M. R. Balsamo;J. P. Giles;S. Krugman;G. S. Mirick
尽管风疹几乎总是一种轻微的自限性疾病，很少伴有任何类型的并发症或后遗症，但许多研究已经确定，在怀孕前三个月感染风疹的妇女的后代中至少有15%至20%患有一种或多种严重的和明显的先天性畸形。另外20%至30%的此类儿童被发现有一定程度的听力障碍。9母亲在怀孕期间发生风疹越早，对胎儿的危害越大;因此，在怀孕的前四周感染风疹的妇女所生的儿童中，50%或更多可能患有先天性巨
ALTHOUGH RUBELLA is almost invariably a mild, self-limited disease seldom followed by complications or sequelae of any kind, numerous studies have established that at least 15% to 20% of the offspring of women who contract German measles during the first trimester of pregnancy are afflicted with one or more serious and grossly discernible congenital malformations.1-8Moreover, if audiometric studies are done, an additional 20% to 30% of such children are found to have some impairment of hearing.9The earlier in pregnancy that maternal rubella occurs, the greater is the hazard to the fetus; thus, 50% or more of the children born of women contracting rubella during the first four weeks of pregnancy may have gross congenital