The role of 5-HT1A receptors in the behavioral responses associated with innate fear.
The role of 5-HT1A receptors in the behavioral responses associated with innate fear.
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DOI：
10.1037/0735-7044.122.3.611
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发表时间：
2008-06
影响因子：
1.9
通讯作者：
J. Shields;J. King
中科院分区：
文献类型：
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作者：
J. Shields;J. King
恐惧是由威胁性刺激引起的反应，是一种重要的适应性系统。5-羟色胺(5-HT)系统已被证明参与了恐惧反应和焦虑症的调节。在临床前研究中，5-HT1A激动剂R(+)-8-羟基-8-二丙基氨基四氢呋喃(8-OHDPAT)具有抗焦虑作用。然而，8-OHDPAT在无条件恐惧中的潜在作用尚未阐明。本研究旨在研究8-OHDPAT对先天恐惧诱导刺激的行为和HPA轴功能的影响。8-OHDPAT预处理后，在接触到狐狸粪便提取物2，5-二氢-2，4，5-三甲基噻唑啉(TMT)后，冷冻美容和攀登的次数显著减少，接近的次数显著增加。TMT是一种无条件的恐惧诱导刺激。此外，8-OHDPAT预处理还导致血皮质酮水平显著降低，皮质酮是HPA激活的标志。综上所述，这些结果表明，8-OHDPAT在先天恐惧范式中还有一种类似缺氧的额外效应。
Fear is a response induced by threatening stimuli and represents an important adaptive system. The serotonin (5-HT) system has been shown to be involved in the modulation of fear responses and anxiety disorders. In preclinical studies, it has been demonstrated that R (+)-8-hydroxy-dipropylaminotetralin (8-OHDPAT), a 5-HT1A agonist, has anxiolytic properties. However, 8-OHDPATs potential role in unconditioned fear has yet to be elucidated. The current study was designed to investigate the effects of 8-OHDPAT on behavioral and HPA axis function in response to an innate fear-inducing stimulus. Pretreatment with 8-OHDPAT resulted in a significant decrease in freezing grooming, and climbing and caused a significant increase in approach after exposure to an extract from fox feces, 2,5-dihyrdo-2,4,5-trimethylthiazoline (TMT), an unconditioned fear-inducing stimulus. Furthermore, 8-OHDPAT pretreatment also resulted in a significant decrease in blood corticosterone levels, a marker of HPA activation. Taken together, these results suggest an additional anxyolitic-like effect of 8-OHDPAT in innate fear paradigms.