Passive stiffness is increased in soleus muscle of desmin knockout mouse
Passive stiffness is increased in soleus muscle of desmin knockout mouse
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DOI：
10.1002/mus.1115
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发表时间：
2001-08-01
期刊：
影响因子：
3.4
通讯作者：
Goubel, F
中科院分区：
文献类型：
--
作者：
Anderson, J;Li, ZL;Goubel, F
使用来自结蛋白敲除小鼠的比目鱼肌分析结蛋白缺失对骨骼肌被动僵硬的影响。通过分析斜升-保持伸展试验引起的被动张力来评估刚度。该测试表明，缺乏结蛋白的肌肉对拉伸的被动阻力大大增加。这项研究有助于解释结蛋白相关肌病患者肌肉力学的变化。(C)John Wiley & Sons，Inc.
The effects of an absence of desmin on passive stiffness of skeletal muscle were analyzed using soleus muscles from desmin knockout mice. Stiffness was evaluated by analyzing the passive tension induced by a ramp-and-hold extension test. This test showed that passive resistance to stretch was largely increased for muscles lacking desmin. This study could facilitate interpretation of changes in muscle mechanics observed in humans affected by desmin-related myopathies. (C) 2001 John Wiley & Sons, Inc.