MYOCARDIAL NECROSIS, FIBROSIS, AND DNA-SYNTHESIS IN EXPERIMENTAL CARDIAC-HYPERTROPHY INDUCED BY SUDDEN PRESSURE OVERLOAD
MYOCARDIAL NECROSIS, FIBROSIS, AND DNA-SYNTHESIS IN EXPERIMENTAL CARDIAC-HYPERTROPHY INDUCED BY SUDDEN PRESSURE OVERLOAD
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DOI：
10.1161/01.res.39.2.238
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发表时间：
1976-01-01
影响因子：
20.1
通讯作者：
MELSEN, LR
中科院分区：
文献类型：
--
作者：
BISHOP, SP;MELSEN, LR
研究了11只肺动脉条带化的猫、6只升主动脉条带化的兔和8只各种先天性心脏异常的猫因心肌肥厚而导致心肌纤维化的发展。心肌的组织学检查显示，猫的右心室和兔的左心室分别有多灶性变性和坏死，并伴有纤维化愈合，其中右心室是肺动脉带状，左心室是主动脉带状。在8只患有先天性异常的猫中，有5只没有出现心肌坏死和纤维化，尽管心脏重量与体重的比例是实验模型的2-4倍。在其他3只猫中，纤维化是心内膜下或弥漫性的，而不是像带状动物那样是多灶性的。在主动脉或肺动脉捆扎引起的心脏肥厚动物中发现的结缔组织增加可能是该制剂的产物。肺动脉带状猫心肌的放射自显像研究表明，该模型中所有新合成的DNA都局限于间质细胞和内皮细胞的增殖。
The development of myocardial fibrosis as a result of cardiac hypertrophy was studied in 11 cats in which the pulmonary artery was banded, 6 rabbits in which the ascending aorta was banded, and 8 cats with various congenital cardiac anomalies. Histological examination of the myocardium revealed multifocal areas of degeneration and necrosis with healing by fibrosis in the right ventricle of cats in which the pulmonary artery was banded and in the left ventricle of rabbits in which the aorta was banded. In 5 of 8 cats with congenital anomalies, myocardial necrosis and fibrosis were not present despite heart weight to body weight ratios 2-4 times greater than in the experimental models. In the other 3 cats, fibrosis was subendocardial or diffuse rather than multifocal as in the banded animals. The increased connective tissue found in animals with cardiac hypertrophy induced by banding the aorta or pulmonary artery may be an artifact of the preparation. Autoradiographic studies of the myocardium of pulmonary artery-banded cats indicated that all newly synthesized DNA in this model is restricted to interstitial cell and endothelial cell proliferation.