PRODH variants and risk for schizophrenia
PRODH variants and risk for schizophrenia
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DOI：
10.1007/s00726-008-0111-0
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发表时间：
2008-06
期刊：
影响因子：
3.5
通讯作者：
A. Willis;H. Bender;G. Steel;D. Valle
中科院分区：
文献类型：
--
作者：
A. Willis;H. Bender;G. Steel;D. Valle
精神分裂症是一种常见的，毁灭性的神经精神障碍，其病因在很大程度上是未知的。在人类、小鼠和苍蝇模型中进行的多项研究表明，脯氨酸和PRODH（编码脯氨酸催化剂途径中第一种酶的基因）在导致精神分裂症风险中发挥作用。然而，其他研究得出了相互矛盾的结论。在这里，我们提供了一个关键的审查的背景下，什么是已知的脯氨酸代谢的数据，并建议为未来的研究。总体而言，有相当多的证据支持某些功能缺失PRODH变体在某些个体中赋予精神分裂症风险的作用。
Schizophrenia is a common, devastating neuropsychiatric disorder whose etiology is largely unknown. Multiple studies in humans and in mouse and fly models suggest a role for proline andPRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia. Other studies, however, reach contradictory conclusions. Here, we provide a critical review of the data in the context of what is known about proline metabolism and suggest studies for the future. Overall, there is considerable evidence supporting a role for certain loss of functionPRODHvariants conferring risk for schizophrenia in some individuals.