Incidence of bone metastases and skeletal-related events in breast cancer patients: a population-based cohort study in Denmark.
Incidence of bone metastases and skeletal-related events in breast cancer patients: a population-based cohort study in Denmark.
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DOI：
10.1186/1471-2407-11-29
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发表时间：
2011-01-24
期刊：
影响因子：
3.8
通讯作者：
Sørensen HT
中科院分区：
文献类型：
--
作者：
Jensen AØ;Jacobsen JB;Nørgaard M;Yong M;Fryzek JP;Sørensen HT
乳腺癌（BrCa）是工业化国家女性中最常见的癌症。超过一半患有转移性乳腺癌的女性会发生骨转移。骨转移增加了骨骼相关事件（SREs）的风险，SREs定义为病理性骨折、脊髓压迫、需要姑息性放疗的骨痛和骨科手术。骨转移和SREs都与不良预后相关，并极大地影响生活质量。很少有流行病学资料显示原发性BrCa和随后的骨转移后的SREs。因此，我们估计了1999年至2007年丹麦新诊断的BrCa患者骨转移和SREs的发生率。从1999年1月1日至2007年12月31日，我们使用丹麦国家患者登记处（DNPR）对丹麦新诊断乳腺癌患者的骨转移和SREs的总体和年发病率进行了估计，该登记处涵盖了所有丹麦医院。我们使用Kaplan-Meier方法估计骨转移和SREs的累积发生率以及相关的95%置信区间（CI）。在35,912例BrCa患者中，178例（0.5%）在原发性乳腺癌诊断时出现骨转移，其中77例（43.2%）在随访期间发生SRE。35,690例（3.6%）诊断时无骨转移的BrCa患者中，有1,272例在3.4年的中位随访期间发生了骨转移。在这些患者中，590例（46.4%）在中位随访时间0.7年期间发生SRE。在原发性BrCa诊断后的第一年，骨转移的发病率最高，特别是在诊断为晚期BrCa的患者中。同样，首次SRE的发病率在首次诊断骨转移后的第一年最高。在首次诊断骨转移后的第一年，SREs的高发病率强调了早期BrCa检测和研究有效治疗延迟SREs发病的必要性。
Breast cancer (BrCa) is the most commonly diagnosed cancer among women in the industrialized world. More than half of women presenting with metastatic BrCa develop bone metastases. Bone metastases increase the risk of skeletal-related events (SREs), defined as pathological fractures, spinal cord compression, bone pain requiring palliative radiotherapy, and orthopaedic surgery. Both bone metastases and SREs are associated with unfavorable prognosis and greatly affect quality of life. Few epidemiological data exist on SREs after primary diagnosis of BrCa and subsequent bone metastasis. We therefore estimated the incidence of bone metastases and SREs in newly-diagnosed BrCa patients in Denmark from 1999 through 2007. We estimated the overall and annual incidence of bone metastases and SREs in newly-diagnosed breast cancer patients in Denmark from January 1, 1999 to December 31, 2007 using the Danish National Patient Registry (DNPR), which covers all Danish hospitals. We estimated the cumulative incidence of bone metastases and SREs and associated 95% confidence intervals (CI) using the Kaplan-Meier method. Of the 35,912 BrCa patients, 178 (0.5%) presented with bone metastases at the time of primary breast cancer diagnosis, and of these, 77 (43.2%) developed an SRE during follow up. A total of 1,272 of 35,690 (3.6%) BrCa patients without bone metastases at diagnosis developed bone metastases during a median follow-up time of 3.4 years. Among these patients, 590 (46.4%) subsequently developed an SRE during a median follow-up time of 0.7 years. Incidence rates of bone metastases were highest the first year after the primary BrCa diagnosis, particularly among patients with advanced BrCa at diagnosis. Similarly, incidence rates of a first SRE was highest the first year after first diagnosis of a bone metastasis. The high incidence of SREs following the first year after first diagnosis of a bone metastasis underscores the need for early BrCa detection and research on effective treatments to delay the onset of SREs.
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影响因子：
158.5
作者：
Hortobagyi, GN;Theriault, RL;Reitsma, DJ
通讯作者：
Reitsma, DJ
影响因子：
4.9
作者：
Sogaard, Kirstine Kobberoe;Cronin-Fenton, Deirdre P.;Lash, Timothy L.
通讯作者：
Lash, Timothy L.
影响因子：
45.3
作者：
Hortobagyi, GN;Theriault, RL;Reitsma, DJ
通讯作者：
Reitsma, DJ
影响因子：
3.8
作者：
Dent, Rebecca;Hanna, Wedad M.;Narod, Steven A.
通讯作者：
Narod, Steven A.
影响因子：
2.3
作者：
Louwman, W. J.;Voogd, A. C.;Coebergh, J. W. W.
通讯作者：
Coebergh, J. W. W.