Types of neural guides and using nanotechnology for peripheral nerve reconstruction.
Types of neural guides and using nanotechnology for peripheral nerve reconstruction.
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DOI：
10.2147/ijn.s11883
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发表时间：
2010-10-21
影响因子：
8
通讯作者：
Roviemiab Z
中科院分区：
文献类型：
--
作者：
Biazar E;Khorasani MT;Montazeri N;Pourshamsian K;Daliri M;Rezaei M;Jabarvand M;Khoshzaban A;Heidari S;Jafarpour M;Roviemiab Z
周围神经损伤可导致终身功能丧失和永久性毁容。不同的方法，如传统的同种异体移植手术和使用生物管，在用于受损周围神经重建时存在问题。由天然材料和合成材料组成的设计支架目前广泛用于损伤组织的重建。利用具有独特特性的可吸收性和不可吸收性的合成聚合物和天然聚合物是修复受损神经组织的一种合适的解决方案。高分子纳米纤维支架具有类似神经结构的特性，在重建过程中更有效。更好的细胞粘附和迁移能力，更强的轴突导向性，以及孔隙度等结构特征，为纳米纤维在神经组织修复中的作用提供了更清晰的线索。本文综述了外周神经损伤的基本概念、人工和自然导向器的类型以及提高导管性能的方法，如定向、纳米技术在神经重建中的应用、纤维和纳米纤维、静电纺丝方法及其在外周神经重建中的应用。
Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Different methods, such as conventional allograft procedures and use of biologic tubes present problems when used for damaged peripheral nerve reconstruction. Designed scaffolds comprised of natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and nonabsorbable synthetic and natural polymers with unique characteristics can be an appropriate solution to repair damaged nerve tissues. Polymeric nanofibrous scaffolds with properties similar to neural structures can be more effective in the reconstruction process. Better cell adhesion and migration, more guiding of axons, and structural features, such as porosity, provide a clearer role for nanofibers in the restoration of neural tissues. In this paper, basic concepts of peripheral nerve injury, types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application in peripheral nerve reconstruction are reviewed.