Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms
Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms
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DOI：
10.1111/j.1600-0404.2006.00600.x
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发表时间：
2006-06-01
影响因子：
3.5
通讯作者：
Min, KT
中科院分区：
文献类型：
--
作者：
Cho, ZH;Hwang, SC;Min, KT
目的 - 尽管针灸疗法已在多个临床领域被证明是有效的，但针灸的一般基本机制和特别是镇痛作用仍不清楚。因此，我们通过功能磁共振成像研究了针灸镇痛作用，并根据所得结果提出了一个假设，这将有助于阐明大脑在针灸治疗中的核心作用。方法 - 所提出的模型被称为广义下丘脑-垂体-肾上腺 (BS-HPA) 轴，基于我们观察到的神经影像学结果。该模型将应激诱导的 HPA 轴模型与神经免疫相互作用（包括胆碱能抗炎模型）结合在一起。结果 - 所获得的结果加上不断积累的证据表明，中枢神经系统通过调节自主神经系统、神经免疫系统和激素调节，对于处理这些效应至关重要。结论 - 根据我们的功能磁共振成像研究，在基于神经科学的框架内了解针灸的效果至关重要。此外，我们结合实验结果提出了广义的HPA轴假说。
Objectives - Athough acupuncture therapy has demonstrated itself to be effective in several clinical areas, the underlying mechanisms of acupuncture in general and the analgesic effect in particular are, however, still not clearly delineated. We, therefore, have studied acupuncture analgesic effect through fMRI and proposed a hypothesis, based on the obtained result, which will enlighten the central role of the brain in acupuncture therapy. Methods - The proposed model, termed as a broad sense hypothalamus-pituitary-adrenal (BS-HPA) axis, was based on our observed neuroimaging results. The model incorporates the stress-induced HPA axis model together with neuro-immune interaction including the cholinergic anti-inflammatory model. Results - The obtained results coupled with accumulating evidence suggest that the central nervous system is essential for the processing of these effects via its modulation of the autonomic nervous system, neuroimmune system and hormonal regulation. Conclusions - Based on our fMRI study, it appears that understanding the effects of acupuncture within a neuroscience-based framework is vital. Further, we have proposed the broad sense-HPA axis hypothesis which incorporates the experimental results.