Failure to Induce Neonatal Tolerance in Mice That Lack Both IL-4 and IL-13 but Not in Those That Lack IL-4 Alone1
Failure to Induce Neonatal Tolerance in Mice That Lack Both IL-4 and IL-13 but Not in Those That Lack IL-4 Alone1
复制标题
同时缺乏 IL-4 和 IL-13 的小鼠无法诱导新生儿耐受，但单独缺乏 IL-4 的小鼠则不然1
作者：
Y. Inoue;B. Konieczny;M. Wagener;A. McKenzie;Fadi G Lakkis
目前的证据表明，新生儿对外源抗原的耐受性是IL-4介导的Th 2免疫的结果，而不是胸腺Ag特异性T细胞的缺失。在这里，我们通过测试是否可以在缺乏IL-4（IL-4−/−）的新生小鼠中诱导对次要组织相容性Ag的耐受来解决IL-4在新生耐受中的作用。我们发现IL-4在新生儿耐受诱导中不起主导作用，因为新生雌性IL-4−/−小鼠可以容易地耐受H-Y雄性Ag。相比之下，缺乏IL-4和IL-13的小鼠（IL-4−/−/IL-13−/−）对新生儿耐受的诱导具有抵抗性，并且它们的脾细胞在用新生儿期间遇到的相同抗原再次激发时产生过量的IFN-γ。这些发现反驳了IL-4单独对诱导新生儿耐受至关重要的观点，并表明IL-4和IL-13的联合作用对该过程至关重要。
Current evidence suggests that neonatal tolerance to a foreign Ag is the consequence of IL-4-mediated Th2 immunity rather than the thymic deletion of Ag-specific T cells. Here, we addressed the role of IL-4 in neonatal tolerance by testing whether tolerance to a minor histocompatibility Ag can be induced in newborn mice that lack IL-4 (IL-4−/−). We found that IL-4 does not play a dominant role in the induction of neonatal tolerance as newborn female IL-4−/− mice could be readily tolerized to the H-Y male Ag. In contrast, mice that lack both IL-4 and IL-13 (IL-4−/−/IL-13−/−) were resistant to the induction of neonatal tolerance, and their splenocytes produced exaggerated amounts of IFN-γ on rechallenge with the same Ag encountered during the neonatal period. These findings argue against the view that IL-4 alone is critical for the induction of neonatal tolerance and suggest that the combined actions of both IL-4 and IL-13 are essential for this process.
II 类同种抗原诱导新生儿耐受可激活分泌 IL-4 的耐受原反应性 T 细胞。
DOI：
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发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
PowellJr,TJ;Streilein,JW
通讯作者：
Streilein,JW
IL-4 缺陷的 C57BL/6 小鼠中曼氏血吸虫病的肉芽肿反应不会转变为 Th1。
DOI：
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发表时间：
1996
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Metwali,A;Elliott,D;Blum,AM;Li,J;Sandor,M;Lynch,R;Noben-Trauth,N;Weinstock,JV
通讯作者：
Weinstock,JV