Autoantibodies against tumor-associated antigens in the early detection of lung cancer
Autoantibodies against tumor-associated antigens in the early detection of lung cancer
复制标题
抗肿瘤相关抗原的自身抗体在肺癌早期检测中的应用
DOI：
10.1016/j.lungcan.2016.07.018
复制
发表时间：
2016-09-01
期刊：
影响因子：
5.3
通讯作者：
Zhang, Jian-Ying
中科院分区：
文献类型：
--
作者：
Dai, Liping;Tsay, Jun-Chieh J.;Zhang, Jian-Ying
目的：在晚期肺癌患者中鉴定的针对肿瘤相关抗原（TAA）的自身抗体可以在早期肺癌受试者中检测到，甚至可以在诊断之前检测到。本研究的目的是解决肺癌的发展和血清自身抗体responsibility.Materials和方法之间的时间关系：两个队列的新诊断的肺癌患者。第一组包括90份来自肺癌患者（I-III期）的血清和89份正常对照血清。在第二个队列中，在肺癌诊断前（平均32个月）收集了来自25名CT扫描筛查检测到的I期肺癌患者的93个系列血清样本，并在年龄，性别和吸烟方面匹配了56名对照。免疫分析法测定自身抗体水平。抗7种TAA自身抗体的测定（14-3-3 zeta c-Myc、MDM 2、NPM 1、p16、p53和细胞周期蛋白B1）单独可以区分第一队列中的肺癌患者与正常个体，曲线下面积（AUC）为0.863基于一组七种自身抗体，敏感性68.9%，特异性79.5%。在肺癌诊断前检测系列诊断前血清样品中针对同一组7种TAA的自身抗体，灵敏度为76.0%，特异性为73.2%（AUC）（95%CI）：0.885（0.797-0.973））。升高的自身抗体水平可以检测到大于4年前肺癌diagnosis.Conclusion：一组7 TAAs可以提高肺癌的早期检测，符合体液免疫反应TAAs，可以检测到几个月到几年前的诊断。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Objectives: Autoantibodies against tumor-associated antigens (TAAs) identified in patients with advanced lung cancer may be detected in subjects with early lung cancer or even predate the diagnosis. The purpose of this study is to address the temporal relationship between lung cancer development and serum autoantibody response.Materials and methods: Two cohorts of patients with newly diagnosed lung cancer were included. The first cohort included 90 sera from patients with lung cancer (Stages I-III) and 89 normal control sera. In the second cohort, 93 serial serum samples from 25 patients with CT-scan screen-detected stage I lung cancer were collected before the diagnosis of lung cancer (average 32 months) and 56 controls were matched on age, gender, and smoking. Autoantibody levels were measured by immunoassay.Results: Measurement of autoantibodies against seven TAAs (14-3-3 zeta c-Myc, MDM2, NPM1, p16, p53 and cyclin B1) individually could discriminate lung cancer patients from normal individuals in the first cohort and the area under curve (AUC) was 0.863 based on a panel of seven autoantibodies, with sensitivity of 68.9% and specificity of 79.5%. Autoantibodies in serial pre-diagnostic serum samples against the same panel of seven TAAs were detected prior to lung cancer diagnosis with sensitivity of 76.0% and specificity of 73.2% (AUC) (95%CI): 0.885 (0.797-0.973)). Elevated autoantibody levels could be detected greater than four years prior to lung cancer diagnosis.Conclusion: A panel of seven TAAs may enhance the early detection of lung cancer, consistent with a humoral immune response to TAAs that can be detected months to years prior to the diagnosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.