Grafting in the mammalian central nervous system.
Grafting in the mammalian central nervous system.
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移植到哺乳动物中枢神经系统中。
DOI：
10.1152/physrev.1993.73.3.583
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发表时间：
1993
影响因子：
33.6
通讯作者：
Gage,FH
中科院分区：
文献类型：
--
作者：
Fisher,LJ;Gage,FH
在过去的一个世纪里，脑内移植已经成为探索中枢神经系统(CNS)发育、功能和可塑性的一种强有力的方法。在早期的研究中，嫁接主要用于研究中枢神经系统的发育和再生(1‘74,179,197,220,221,262,265,266,271)。最近的工作越来越重视移植物的使用，以了解神经系统之间的解剖和功能相互作用，以及修复或重建中枢神经系统的受损区域。然而，在最近将分子生物学技术引入嫁接策略的帮助下，中枢神经系统的发育和可塑性问题继续引起极大的兴趣。最后，移植已经进入临床领域，这一举动引起了极大的兴趣和争议。
Over the past century, intracerebral grafting has evolved as a powerful method for exploring the development, function, and plasticity of the central nervous system (CNS). In early studies, grafting was primarily used as a technique for examining CNS development and regeneration (1’74, 179,197, 220, 221, 262, 265, 266, 271). More recent work has increasingly emphasized the use of grafts to understand the anatomic and functional interactions between neural systems and to repair or reconstruct damaged regions of the CNS. However, issues in CNS development and plasticity continue to be pursued with great interest, aided by the recent introduction of molecular biology techniques into the grafting strategy. Finally, grafting has moved into the clinical arena, a move which has generated significant interest and controversy.