Making anti-cytokine therapy more selective: Studies in mice
Making anti-cytokine therapy more selective: Studies in mice
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DOI：
10.1016/j.cyto.2016.08.022
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发表时间：
2018-01-01
期刊：
影响因子：
3.8
通讯作者：
Nedospasov, Sergei A.
中科院分区：
文献类型：
--
作者：
Drutskaya, Marina S.;Efimov, Grigory A.;Nedospasov, Sergei A.
细胞因子参与塑造正常免疫反应的广泛功能，但由于细胞因子信号传导失调而导致的免疫系统炎症变化可能导致自身免疫的诱导。近年来，细胞因子抑制剂彻底改变了许多自身免疫性疾病的治疗。然而，全身细胞因子消融通常与不良副作用的发生有关，并且一些患者根本对治疗没有反应。 TNF、IL-1 和 IL-6 是特征最明确的促炎细胞因子，被认为是治疗多种自身免疫性疾病和炎症性疾病的主要治疗靶点。但抗细胞因子治疗能否变得更具选择性并因此更有效？这篇小评论讨论了几个最近出现的范例，并总结了当前在小鼠研究中验证它们的实验尝试。 (C) 2016 年由爱思唯尔有限公司出版。
Cytokines are involved in a wide range of functions shaping the normal immune response, yet inflammatory changes in the immune system due to dysregulated cytokine signaling may lead to the induction of autoimmunity. Cytokine inhibitors have revolutionized the treatment of many autoimmune diseases in recent years. Systemic cytokine ablation, however, is often associated with the development of adverse side effects and some patients simply do not respond to therapy. TNF, IL-1 and IL-6 are the best characterized proinflammatory cytokines considered as the main therapeutic targets for the treatment of several autoimmune and inflammatory diseases. But can anti-cytokine therapy become more selective and thus more efficient? This mini-review discusses several recently emerging paradigms and summarizes current experimental attempts to validate them in mouse studies. (C) 2016 Published by Elsevier Ltd.