Intranasal oxytocin fails to acutely improve glucose metabolism in obese men
Intranasal oxytocin fails to acutely improve glucose metabolism in obese men
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DOI：
10.1111/dom.13527
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发表时间：
2019-02-01
影响因子：
5.8
通讯作者：
Klement, Johanna
中科院分区：
文献类型：
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作者：
Brede, Swantje;Fehr, Sebastian;Klement, Johanna
下丘脑神经肽催产素不仅调节社会心理功能，还参与代谢调节。我们最近的研究表明，在正常体重的男性中，鼻内催产素能显著改善β细胞的反应性和葡萄糖耐量。在本实验中，我们研究了催产素对胰岛素敏感性受损的肥胖男性的急性血糖调节作用。15名肥胖健康男性，平均体重指数为35 kg/m(2)，平均体脂含量为33%，在接受口服葡萄糖耐量试验之前，接受单次鼻内剂量（24 IU）的催产素。根据口腔最小模型对结果进行分析，并与正常体重参与者的结果进行比较。与正常体重的受试者相比，催产素并不能抑制肥胖男性餐后血糖和胰岛素的升高，而且也不能增强β细胞的反应性和葡萄糖耐量。这些结果表明，明显的肥胖可能与外源性催产素对血糖调节作用的一定程度的抵抗有关，并强调了在临床背景下进一步研究催产素改善葡萄糖稳态的潜力的必要性。
The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta-cell responsivity and glucose tolerance in normal-weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen obese healthy men with an average body mass index of 35 kg/m(2) and an average body fat content of 33% received a single intranasal dose (24 IU) of oxytocin before undergoing an oral glucose tolerance test. Results were analysed according to the oral minimal model and compared with our findings in normal-weight participants. In contrast to the results in normal-weight subjects, oxytocin did not blunt postprandial glucose and insulin excursions in obese men, and moreover failed to enhance beta-cell responsivity and glucose tolerance. These results indicate that pronounced obesity may be associated with a certain degree of resistance to the glucoregulatory impact of exogenous oxytocin, and underlines the need for further investigations into the potential of oxytocin to improve glucose homeostasis in the clinical context.