The microbiology of ligature-induced periodontitis in the cynomolgus monkey.
The microbiology of ligature-induced periodontitis in the cynomolgus monkey.
复制标题
食蟹猴结扎引起的牙周炎的微生物学。
DOI：
10.1111/j.1600-0765.1981.tb00987.x
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发表时间：
1981
影响因子：
3.5
通讯作者：
Robertson,PB
中科院分区：
文献类型：
--
作者：
Kornman,KS;Holt,SC;Robertson,PB
在结扎诱导自然发生的牙龈炎发展为牙周炎的过程中，对食蟹猴（Macaca fasciculis）可培养的龈下微生物群进行了监测。临床和微生物学观察分为四个阶段。 I 期，在结扎术之前，临床特征为慢性牙龈炎，微生物学特征为革兰氏阳性球菌和 B 型杆菌。 melaninogenicusss.intermedius占主导地位的革兰氏阴性生物。第二阶段，即结扎后 1 至 3 周，牙龈炎症稍严重，但没有附着丧失的临床证据。龈下菌群显示活动性和表面易位革兰氏阴性杆菌显着增加，主要是二氧化碳噬菌体物种和痰弯曲杆菌。第三阶段，即结扎后 4 至 7 周，显示牙周袋深度增加和牙槽骨丢失的放射学证据。这个阶段的特点是革兰氏阴性厌氧菌群和 B.解糖酵母是主要的可培养生物。 IV阶段包括实验期的剩余时间，即8至17周，在此期间临床参数和B水平没有发生进一步的变化。食蟹猴结扎引起的牙周炎的龈下微生物群与报道的人类牙周病非常相似，并且附着丧失的阵发性临床模式与革兰氏阴性厌氧菌（主要是解糖杆菌）的水平相关。
The cultivable subgingival microflora in the cynomolgus monkey,Macaca fascicularis, was monitored during the ligature‐induced progression of naturally occurring gingivitis to periodontitis. Clinical and microbiological observations were divided into four stages. Stage I, prior to ligature placement, was characterized clinically by chronic generalized gingivitis and microbiologically by Gram‐positive cocci and rods withB. melaninogenicusss.intermediusthe dominant Gram‐negative organism. Stage II, 1 to 3 weeks following ligature placement, exhibited slightly greater gingival inflammation but no clinical evidence of attachment loss. The subgingival flora showed a significant increase in motile and surface translocating Gram‐negative rods, primarilyCapnocytophagaspecies andCampylobacter sputorum. Stage III, 4 to 7 weeks following ligature placement, revealed increased pocket depth and radiographic evidence of alveolar bone loss. This stage was characterized by a Gram‐negative anaerobic flora withB. asaccharolyticusas the dominant cultivable organism. Stage IV encompassed the remainder of the experimental period, 8 to 17 weeks, during which time no further change in the clinical parameters occurred and levels ofB. asaccharolyticusdecreased.The subgingival microflora of ligature induced periodontitis inMacaca fascicularisclosely resembled that reported for human periodontal disease and the episodic clinical pattern of attachment loss was associated with levels of Gram‐negative anaerobes, primarilyB.asaccharolyticus.