The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
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DOI：
10.1158/1940-6207.capr-20-0542
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发表时间：
2021-12-01
影响因子：
3.3
通讯作者：
Kang, Mira
中科院分区：
文献类型：
--
作者：
Kang, Danbee;Kim, Ji-Yeon;Kang, Mira
背景资料：本研究的目的是探讨绝经期乳腺密度变化与乳腺癌发病风险之间的关系。方法：本研究是一项回顾性纵向队列研究，对象为30岁以上的女性，她们在基线和绝经后定期健康检查时连续接受乳腺钼靶摄影。没有参与者在基线时被诊断患有乳腺癌。乳腺摄影乳腺密度测量使用美国放射学会乳腺成像报告和数据System.Results：在18,615人年的后续行动（中位数随访4.8年，四分位数范围2.8-7.5年），45名参与者被诊断为乳腺癌。致密乳房的患病率在那些年轻、体重不足、产次低或使用避孕药具的人中更高。参与者绝经后4年乳腺癌的累积发病率增加，与其他组相比，持续极密集组的乳腺癌累积发病率（CI）显著更高[极密集组与其他组的CI（每10万人-年的发病率）：375 vs. 203，P < 0.01]。绝经前乳腺密度极高的韩国女性和绝经后保持这一密度的韩国女性患乳腺癌的风险增加两倍。预防相关性：在韩国妇女中，从绝经前到绝经后持续保持极高的乳腺密度会使乳腺癌的风险增加两倍。因此，有风险因素的妇女应经常接受乳房X光检查，如果检测到持续的极致密乳腺，可以考虑进行额外的BC筛查。
Background: The aim of this study was to investigate the relationship between changes in breast density during menopause and breast cancer risk.Methods: This study was a retrospective, longitudinal cohort study for women over 30 years of age who had undergone breast mammography serially at baseline and postmenopause during regular health checkups at Samsung Medical Center. None of the participants had been diagnosed with breast cancer at baseline. Mammographic breast density was measured using the American College of Radiology Breast Imaging Reporting and Data System.Results: During 18,615 person-years of follow-up (median follow-up 4.8 years; interquartile range 2.8-7.5 years), 45 participants were diagnosed with breast cancer. The prevalence of dense breasts was higher in those who were younger, underweight, had low parity or using contraceptives. The cumulative incidence of breast cancer increased 4 years after menopause in participants, and the consistently extremely dense group had a significantly higher cumulative incidence (CI) of breast cancer compared with other groups [CI of extremely dense vs. others (incidence rate per 100,000 person-years): 375 vs. 203, P < 0.01].Conclusion: Korean women whose breast density was extremely dense before menopause and who maintained this density after menopause were at two-fold greater risk of breast cancer.Prevention Relevance: Extremely dense breast density that is maintained persistently from premenopause to postmenopause increases risk of breast cancer two fold in Korean women. Therefore, women having risk factors should receive mammography frequently and if persistently extremely dense breast had been detected, additional modalities of BC screening could be considered.