Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1α inhibit signaling by KSHV G protein-coupled receptor
Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1α inhibit signaling by KSHV G protein-coupled receptor
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DOI：
10.1006/bbrc.1998.9557
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发表时间：
1998-12-30
影响因子：
3.1
通讯作者：
Gershengorn, MC
中科院分区：
文献类型：
--
作者：
Geras-Raaka, E;Varma, A;Gershengorn, MC
卡波西肉瘤相关疱疹病毒(KSHV)编码两种类似于人类CC趋化因子的蛋白质和一种具有结构性活性的G蛋白偶联受体(KSHV-GPCR)。KSHV-GPCR可与多种人CXC和CC趋化因子结合。我们发现干扰素γ诱导蛋白-10(IP-10)，一种人类CXC趋化因子，抑制KSHV-GPCR信号转导(Geras-Raaka等人，J.Exp。地中海医院。188,405-408,1998)。在这里，我们发现病毒单核细胞炎症蛋白-II(vMIP-II)，KSHV编码的CC趋化因子之一，和基质细胞衍生因子1α(SDF-1α)，人类CXC趋化因子，阻断人类免疫缺陷病毒1型感染，也抑制KSHV-GPCR信号转导。如果KSHV-GPCR信号参与了病毒的发病机制，那么这些趋化因子可能影响Kaposi肉瘤和原发渗出性淋巴瘤的病程。(C)1998年学术出版社。
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes two proteins that are similar to human CC chemokines and a G protein-coupled receptor (KSHV-GPCR) that is constitutively active. KSHV-GPCR binds a number of human CXC and CC chemokines. We showed that interferon gamma-inducible protein-10 (IP-10), a human CXC chemokine, inhibits KSHV-GPCR signaling (Geras-Raaka et al., J. Exp. Med. 188, 405-408, 1998). Here we show that viral monocyte inflammatory protein-II (vMIP-II), one of the KSHV-encoded CC chemokines, and stromal cell-derived factor 1 alpha (SDF-1 alpha), a human CXC chemokine that blocks infection by human immunodeficiency virus-type 1, inhibit KSHV-GPCR signaling also. If KSHV-GPCR signaling is involved in viral pathogenesis, then these chemokines may affect the course of Kaposi's sarcoma and primary effusion lymphoma. (C) 1998 Academic Press.