Forward electrical transmission line model of the human arterial system
Forward electrical transmission line model of the human arterial system
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DOI：
10.1007/bf02344705
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发表时间：
2004-05-01
影响因子：
3.2
通讯作者：
John, LR
中科院分区：
文献类型：
--
作者：
John, LR
本文提出了一种计算外周阻抗的新方法，建立了一个基于输电线类比的人体动脉系统的正向数学模型。将正常和狭窄动脉条件下的人体动脉系统的模拟与其他已发表的模拟以及测量的临床数据和已知的临床定量进行比较。和定性特征：谐波动脉输入阻抗谱分别与等效模拟和生理数据相比，平均误差为0.07-0.1 mmHg.s.cm（-1）;沿着动脉树的血压和流量波形的定性和定量变化符合临床趋势;动脉脉搏波速度与接近主动脉根部的生理数据相比是有利的（-50-20cm s（-1）差异），但外周差异较大（149-1192 cm s（-1）差）;进行性狭窄动脉疾病的血流波形的定性和定量变化，如通过脉动指数测量的，与临界狭窄的平均临床数据相比，误差在2 - 16%之间。在给定的测试条件下，前向模型被发现密切代表临床观察到的人体动脉系统的血液动力学特性。
A forward mathematical model of the human arterial system, based on an electrical transmission line analogy, has been developed, using a new method for the calculation of peripheral impedance. Simulations of the human arterial system under normal and stenotic arterial conditions were compared with other published simulations, as well as measured clinical data and known clinical quantitative. and qualitative characteristics: the harmonic arterial input impedance spectrum demonstrated a mean error of 0.07-0.1 mmHg.s.cm(-1), compared with equivalent simulation and physiological data, respectively; qualitative and quantitative variation of blood pressure and flow waveforms along the arterial tree followed clinical trends; arterial pulse wave velocities compared favourably with physiological data close to the aortic root (-50-20cm s(-1) difference), but there were larger differences in the periphery (149-1192 cm s(-1) difference); qualitative as well as quantitative variation of blood flow waveforms with progressive stenotic arterial disease, as measured by the pulsatility index, demonstrated an error between 2 and 16% in comparison with mean clinical data for critical stenosis. Under the given test conditions, the forward model was found closely to represent clinically observed haemodynamic characteristics of the human arterial system.