A plasminogen-related gene is expressed in cancer cells.
A plasminogen-related gene is expressed in cancer cells.
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纤溶酶原相关基因在癌细胞中表达。
DOI：
10.1016/0006-291x(92)90861-e
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发表时间：
1992
影响因子：
3.1
通讯作者：
Treadwell,BV
中科院分区：
文献类型：
--
作者：
Weissbach,L;Treadwell,BV
血凝块的分解需要丝氨酸蛋白酶纤溶酶的纤溶作用，纤溶酶是一种后衍生自其前体酶原纤溶酶原的双链多肽。在研究人肝外组织中纤溶酶原基因表达时，获得了与纤溶酶原cDNA非常相似的cDNA序列，但似乎代表了不同的基因产物。该序列代表最近表征的纤溶酶原相关基因B的转录物，编码Mr8800的推定多肽，并且在恶性癌细胞中最显著地表达。
The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resembled the plasminogen cDNA, yet appeared to represent a distinct gene product. This sequence, which represents the transcript of the recently characterized plasminogen-related gene B, encodes a putative polypeptide of Mr8800 and is expressed most prominently in malignant cancer cells.