Precision medicine: an approach to R&D for delivering superior medicines to patients.
Precision medicine: an approach to R&D for delivering superior medicines to patients.
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DOI：
10.1186/2001-1326-1-7
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发表时间：
2012-05-30
影响因子：
10.6
通讯作者：
Søgaard M
中科院分区：
文献类型：
--
作者：
Dolsten M;Søgaard M
在过去十年中，尽管投资增加，但制药研发生产率却有所下降。然而，最近的趋势表明，这一趋势可能发生逆转，这是由于一波新的生物制剂，疫苗和高度选择性的NCE针对人类遗传学验证的目标，重点关注新的疾病领域，包括孤儿和遗传疾病，以及更精确地为目标人群定制药物。
Pharmaceutical R&D productivity has declined over the last decade despite increasing investments. Recent trends, however, indicate a potential reversal of this trend fueled by a wave of new biologics, vaccines and highly selective NCEs directed against targets validated by human genetics, focus on new disease areas including orphan and genetic diseases and more precise tailoring of medicines to their target populations.