Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle
Immunohistochemical study of matrilin-1 in arthritic articular cartilage of the mandibular condyle
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DOI：
10.1034/j.1600-0714.2003.00093.x
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Tanne, K
中科院分区：
文献类型：
--
作者：
Ohno, S;Murakami, K;Tanne, K
背景：本研究旨在用免疫组织化学方法研究matrlin-1在下颌骨关节病关节软骨中的表达。方法：12例关节炎(骨关节炎和关节内紊乱)患者(平均年龄51.8岁，年龄28~71岁)和4例关节强直患者(平均年龄44.0岁，年龄16~)的髁突软骨标本均经临床和影像检查证实。结果：Matrlin-1在TMJ强直和关节炎患者中均有表达，关节软骨中Matrlin-1表达水平明显高于对照组。产生Matrlin-1的细胞占软骨细胞总数的平均百分比显著高于对照组(P
Background: The objective of this study was to investigate the expression of matrilin-1 in arthritic articular cartilage of the mandibular condyle by means of immunohistochemical methods.Methods: Condylar cartilage specimens were obtained from temporomandibular joints (TMJs) of 12 patients with arthritis (osteoarthritis and internal derangement) (mean age 51.8 years; age range 28-71 years) and four patients with TMJ ankylosis (mean age 44.0 years; age range 16-64 years), diagnosed clinically and with imaging examinations. Paraffin sections were immunostained with anti-matrilin-1 antibodies.Results: Matrilin-1 expression was detected in both patient groups with TMJ ankylosis and arthritis, and the level was remarkably higher in arthritic cartilage. The mean percentage of matrilin-1-producing cells to the total chondrocytes was significantly (P