The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding
The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding
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DOI：
10.1016/j.bbapap.2021.140708
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发表时间：
2021-08-07
影响因子：
3.2
通讯作者：
Hamaguchi，Isao
中科院分区：
文献类型：
--
作者：
Kusunoki，Hideki;Tanaka，Toshiyuki;Hamaguchi，Isao
N93D 肽的 Asp93 和 Nrp1 b1 的四个残基 Trp301、Lys347、Glu348 和 Thr349。我们的结果表明，SU Asp93 与 Nrp1 b1 的四个残基的相互作用使 N93D 突变体在 HTLV-1 进入期间对 Nrp1 b1 结合具有高亲和力。
Asp93 of the N93D peptide and the four residues Trp301, Lys347, Glu348, and Thr349 of Nrp1 b1. Our results suggest that the interaction of SU Asp93 with the four residues of Nrp1 b1 renders the high affinity of the N93D mutant for Nrp1 b1 binding during HTLV-1 entry.