MEDIAL ARTERY CALCIFICATION PREDICTS CARDIOVASCULAR MORTALITY IN PATIENTS WITH NIDDM
MEDIAL ARTERY CALCIFICATION PREDICTS CARDIOVASCULAR MORTALITY IN PATIENTS WITH NIDDM
复制标题
DOI：
10.2337/diacare.17.11.1252
复制
发表时间：
1994-11-01
期刊：
影响因子：
16.2
通讯作者：
UUSITUPA, MI
中科院分区：
文献类型：
--
作者：
NISKANEN, L;SIITONEN, O;UUSITUPA, MI
目的：研究内侧动脉钙化（Monckeberg's sclerosis）与非胰岛素依赖型糖尿病（NIDDM）患者10年心血管死亡率的相关性。研究设计和方法：我们研究了133名新诊断的中年NIDDM患者（70名男性和63名女性）的大腿内侧和内膜动脉钙化对10年心血管死亡率的预测价值。结果：基线时，17%的患者发现内侧动脉钙化，23%的患者发现内膜型钙化。在随访期间，21%的糖尿病患者死于心血管疾病。年龄校正后心血管死亡率的优势比，中位型为4.2(95%可信区间：1.5-11.3)，内膜型为1.6（0.6-4.3）。在包括年龄、性别、收缩压、低密度和高密度脂蛋白胆固醇、极低密度脂蛋白甘油三酯、吸烟、体重指数、空腹血清胰岛素、血糖、尿白蛋白、缺血性心电图变化以及内膜动脉钙化在内的多元logistic回归分析中，内侧动脉钙化是预测心血管死亡率的主要因素。结论：在这项研究中，内侧动脉钙化是新诊断的NIDDM患者心血管死亡率的一个强有力的独立预测因子。这些受试者在诊断前是否比没有内侧动脉钙化的患者有更长的高血糖持续时间尚不清楚。
OBJECTIVE- To study the predictive value of medial artery calcification (Monckeberg's sclerosis) in relation to 10-year cardiovascular mortality in patients with noninsulin-dependent diabetes mellitus (NIDDM).RESEARCH DESIGN AND METHODS- We studied the predictive value of thigh medial and intimal artery calcifications to 10-year cardiovascular mortality in a well-characterized group of 133 middle-aged, newly diagnosed patients with NIDDM (70 men and 63 women).RESULTS- At baseline, medial artery calcifications were found in 17% of the patients and intimal-type calcifications were found in 23%. During the follow-up, 21% of the diabetic patients died from cardiovascular causes. The age-adjusted odds ratio for cardiovascular mortality was 4.2 (95% confidence intervals: 1.5-11.3) for medial-type and 1.6 (0.6-4.3) for intimal-type calcifications. In multiple logistic regression analysis, including age, sex, systolic blood pressure, low-density- and high-density-lipoprotein cholesterol, very-low-density lipoprotein triglycerides, smoking, body mass index, fasting serum insulin, blood glucose, urinary albumin, and ischemic ECG changes, as well as the intimal artery calcification, the medial artery calcification was the dominant factor predicting cardiovascular mortality.CONCLUSIONS - In this study medial artery calcification was a strong independent predictor of cardiovascular mortality in patients with newly diagnosed NIDDM. Whether these subjects had a longer duration of hyperglycemia before the diagnosis than those without medial artery calcifications remains unknown.