In vitro and in vivo effects of progesterone on Trichinella spiralis newborn larvae
In vitro and in vivo effects of progesterone on Trichinella spiralis newborn larvae
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DOI：
10.1017/s0031182005007468
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发表时间：
2005-08-01
期刊：
影响因子：
2.4
通讯作者：
Venturiello, SM
中科院分区：
文献类型：
--
作者：
Nuñez, GG;Gentile, T;Venturiello, SM
我们之前已经证明，在怀孕期间，感染大鼠体内针对旋毛虫新生幼虫（NBL）的杀寄生虫活性增加。在这项工作中，我们分析了非感染的妊娠大鼠的腹膜细胞的NBL细胞毒性试验中的死亡率的贡献，并评估了孕酮在这种效应机制的作用。我们的研究结果表明，黄体酮可以诱导效应腹膜细胞的激活，以快速且不依赖抗体的方式破坏NBL。给卵巢切除的大鼠施用孕酮也导致动物的寄生虫负荷显著降低，从而证明孕酮诱导参与NBL死亡机制的白细胞的杀寄生虫活性增加。
We have previously demonstrated that during pregnancy there exists an increased parasiticide activity against Trichinella spiralis newborn larvae (NBL) in infected rats. In this work we analysed the contribution of peritoneal cells from noninfected pregnant rats to the mortality of the NBL in cytotoxicity assays, and evaluated the role of progesterone in this effector mechanism. Our findings suggest that progesterone can induce activation of effector peritoneal cells to destroy the NBL in a rapid and antibody-independent manner. The administration of progesterone to ovariectomized rats also led to a significant decrease in the parasite load of the animals, thus demonstrating that progesterone induces the increase of the parasiticide activity of the leukocytes involved in the mechanisms of NBL death.