Evidence for altered host genetic factors in KSHV infection and KSHV-related disease development.
Evidence for altered host genetic factors in KSHV infection and KSHV-related disease development.
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KSHV感染和KSHV相关疾病发展中宿主遗传因素改变的证据
DOI：
10.1002/rmv.2160
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发表时间：
2021-03
影响因子：
11.1
通讯作者：
Schäfer G
中科院分区：
文献类型：
--
作者：
Blumenthal MJ;Cornejo Castro EM;Whitby D;Katz AA;Schäfer G
卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤（KS）的病原体，卡波西肉瘤是最常见的艾滋病相关恶性肿瘤。它还引起其他罕见但肯定被低估的KSHV相关病理，即原发性渗出性淋巴瘤，多中心Castleman病和KSHV炎性细胞因子综合征。流行病学和致病性研究指出宿主对KSHV感染的遗传易感性和/或随后发生KSHV相关病理的可能性，部分解释了KSHV和相关病理的特殊地理和人群特异性发病率以及KSHV暴露和感染与KSHV感染和疾病发展的差异。本文综述了目前对KSHV驱动的发病机制中所涉及的宿主遗传因素的认识。本文综述的研究表明，KSHV易感性和宿主遗传因素之间存在合理的联系，这些遗传因素影响病毒通过进入机制进入宿主细胞或宿主对病毒感染的先天免疫。感染后，KSHV相关的发病机制，主要在KS的背景下，可能受到先天免疫系统相互作用，下游炎症途径和致癌机制的协调一致的影响。这里回顾的关联研究指出，有趣的候选基因，可能被证明是重要的，在实现更细致入微的理解KSHV和相关疾病的发病机制和治疗靶向。最近对宿主遗传因素的研究表明，许多候选基因与KSHV感染或随后的疾病发展密切相关，特别是先天免疫系统介质。总之，这些有助于我们了解KSHV和KSHV相关疾病的地理流行率和人群易感性。
Kaposi's sarcoma‐associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), the most common AIDS‐related malignancy. It also causes other rare, but certainly underreported, KSHV‐associated pathologies, namely primary effusion lymphoma, multicentric Castleman disease and KSHV inflammatory cytokine syndrome. Epidemiology and pathogenicity studies point to the potential for host genetic predisposition to KSHV infection and/or the subsequent development of KSHV‐associated pathologies partly explaining the peculiar geographic and population‐specific incidence of KSHV and associated pathologies and discrepancies in KSHV exposure and infection and KSHV infection and disease development. This review consolidates the current knowledge of host genetic factors involved in the KSHV‐driven pathogenesis. Studies reviewed here indicate a plausible connection between KSHV susceptibility and host genetic factors that affect either viral access to host cells via entry mechanisms or host innate immunity to viral infection. Subsequent to infection, KSHV‐associated pathogenesis, reviewed here primarily in the context of KS, is likely influenced by an orchestrated concert of innate immune system interactions, downstream inflammatory pathways and oncogenic mechanisms. The association studies reviewed here point to interesting candidate genes that may prove important in achieving a more nuanced understanding of the pathogenesis and therapeutic targeting of KSHV and associated diseases. Recent studies on host genetic factors suggest numerous candidate genes strongly associated with KSHV infection or subsequent disease development, particularly innate immune system mediators. Taken together, these contribute toward our understanding of the geographic prevalence and population susceptibility to KSHV and KSHV‐associated diseases.
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DOI：
10.1084/jem.20101597
发表时间：
2010-10-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Byun M;Abhyankar A;Lelarge V;Plancoulaine S;Palanduz A;Telhan L;Boisson B;Picard C;Dewell S;Zhao C;Jouanguy E;Feske S;Abel L;Casanova JL
通讯作者：
Casanova JL
影响因子：
5.1
作者：
Camcioglu, Y;Picard, C;Casanova, JL
通讯作者：
Casanova, JL
影响因子：
2.6
作者：
Alkharsah, K. R.;Alzahrani, A. J.;Al-Ali, A. K.
通讯作者：
Al-Ali, A. K.
影响因子：
0.9
作者：
Berber, I;Altaca, G;Titiz, MI
通讯作者：
Titiz, MI
影响因子：
3.8
作者：
Brown, Elizabeth E.;Fallin, Daniele;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.