Nanomorphological Diversity of Self-Assembled Cyclopeptisomes Investigated via Thermodynamic and Kinetic Controls
Nanomorphological Diversity of Self-Assembled Cyclopeptisomes Investigated via Thermodynamic and Kinetic Controls
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DOI：
10.1021/acs.macromol.6b01603
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发表时间：
2016-09
期刊：
影响因子：
5.5
通讯作者：
Soo hyun Kwon;Woo-jin Jeong;Jun Shik Choi;Sanghun Han;Y. Lim
中科院分区：
文献类型：
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作者：
Soo hyun Kwon;Woo-jin Jeong;Jun Shik Choi;Sanghun Han;Y. Lim
The physicochemical and biological characteristics of vesicles are dependent on the type of self-assembly building blocks and methods of preparation. In this report, we designed a vesicle-forming linear and cyclic peptide building blocks and investigated the effect of molecular topology and thermodynamic and kinetic controls on the stability and morphological features of the self-assembled vesicles. Comparison of topological effect on self-assembly revealed that the strong association of the aromatic hydrophobic segments is observed only in the cyclic peptide, which is most likely the results of constrained structure along with the restriction in the molecular degree of freedom. Consequently, the formation of stable vesicles could be observed only with the cyclic peptide. Further investigation with cyclic peptide building blocks revealed that depending on the control methods, vesicles with a variety of structural features, such as polygonal, wrinkled, round, round-patched, and round-fused vesicles, could ...
