A common somitic origin for embryonic muscle progenitors and satellite cells
A common somitic origin for embryonic muscle progenitors and satellite cells
复制标题
DOI：
10.1038/nature03572
复制
发表时间：
2005-06-16
期刊：
影响因子：
64.8
通讯作者：
Marcelle, C
中科院分区：
文献类型：
--
作者：
Gros, J;Manceau, M;Marcelle, C
在胚胎和成年，骨骼肌的生长依赖于肌团内存在的肌祖细胞的增殖和分化。尽管这些祖细胞很重要，但它们的胚胎起源尚不清楚(1，2)。在这里，我们使用绿色荧光蛋白在鸡体节中的电穿孔，细胞运动的视频共聚焦显微镜分析，以及鹌鹑-鸡的移植实验，证明了体节的背侧隔室，皮肤肌节，是一群肌肉前体细胞的起源，有助于胚胎和胎儿期间躯干肌肉的生长。此外，长期的谱系分析表明，卫星细胞是已知的成人骨骼肌祖细胞(4)，它们来自相同的皮肌瘤细胞群。我们得出结论，胚胎肌肉祖细胞和卫星细胞有着共同的起源，可以追溯到皮肌节。
In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear(1,2). Here we use electroporation of green fluorescent protein in chick somites(3), video confocal microscopy analysis of cell movements, and quail-chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles(4), derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.