Estrogen lowers triglyceride via regulating hepatic APOA5 expression.
Estrogen lowers triglyceride via regulating hepatic APOA5 expression.
复制标题
雌激素通过调节肝脏 APOA5 表达降低甘油三酯
DOI：
10.1186/s12944-017-0463-0
复制
发表时间：
2017-04-04
影响因子：
4.5
通讯作者：
Li XP
中科院分区：
文献类型：
--
作者：
Luo F;Guo Y;Ruan GY;Peng R;Li XP
已发现雌激素与血清甘油三酯(TG)水平呈负相关。载脂蛋白A5(ApoA5)是载脂蛋白家族的新成员，具有较强的降血脂作用。临床资料发现，女性载脂蛋白A5浓度高于男性，且载脂蛋白A5与甘油三酯水平的负相关关系在女性更为显著。提示APOA5可能参与雌激素的作用。因此，我们假设雌激素上调血清载脂蛋白A5的浓度，从而降低血清甘油三酯水平。我们将设计以下实验来验证这一假设。(1)我们将用雌激素或不加雌激素处理去卵巢的野生和APOA5缺陷型仓鼠，以检测雌激素是否能上调APOA5的浓度和降低TG水平。(2)用雌激素处理HepG2细胞，并探讨其可能的作用机制。
Estrogen had been found to be negatively associated with serum triglyceride (TG) levels. Apolipoprotein A5 (APOA5), a novel member of apolipoprotein family, was reported to have a strong ability to decrease serum concentrations of TG. Clinical data found concentrations of APOA5 were higher in woman than that in men, and the negative relationship between APOA5 and TG levels was more significant in woman. These suggests APOA5 may involve in estrogen actions. Therefore, we hypothesize estrogen up-regulates serum concentrations of APOA5 and subsequently decreases serum TG levels. We will design the following experiments to test this hypothesis. (1) We will treat wild and APOA5-defeted ovariectomized hamster with or without estrogen to examine if estrogen could up-regulate concentrations of APOA5 and decrease TG levels. (2) We will treat HepG2 cells with estrogen and investigate the possible mechanisms.