Serum levels of folate, lycopene, β-carotene, retinol and vitamin E and prostate cancer risk
Serum levels of folate, lycopene, β-carotene, retinol and vitamin E and prostate cancer risk
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DOI：
10.1038/ejcn.2010.124
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发表时间：
2010-10-01
影响因子：
4.7
通讯作者：
Musk, A. W.
中科院分区：
文献类型：
--
作者：
Beilby, J.;Ambrosini, G. L.;Musk, A. W.
以前的研究表明，血清叶酸和脂溶性维生素水平升高与前列腺癌风险之间存在着各种各样的联系，或者降低或增加患前列腺癌的风险。据报道，血清叶酸水平的前瞻性研究显示，血清叶酸水平升高与随后发生前列腺癌的风险降低或增加无关联。同样，据报道，血清β-胡萝卜素和番茄红素水平与前列腺癌风险呈负相关或无关。采用前瞻性巢式病例对照研究设计，最大限度地减少疾病对血清维生素浓度的影响的可能性，我们报告了血清叶酸，番茄红素，β-胡萝卜素，维生素A和维生素E浓度与前列腺癌的后续发展的零关联。欧洲临床营养学杂志（2010）64，1235-1238; doi：10.1038/ejcn.2010.124; 2010年8月4日在线发表
Previous studies relating increased serum levels of folate and fat-soluble vitamins to prostate cancer risk have variously shown null associations or to either decrease or increase the risk of developing prostate cancer. Prospective studies of serum folate levels have been reported to show a null association and increased serum levels to either decrease or increase the risk of subsequently developing prostate cancer. Similarly, serum beta-carotene and lycopene levels have either been reported to be inversely correlated or not associated with prostate cancer risk. Using a prospective nested case-control study design, which minimized the possibility of disease effects on serum-vitamin concentrations, we report null associations for serum concentrations of folate, lycopene, beta-carotene, vitamin A and vitamin E, and subsequent development of prostate cancer. European Journal of Clinical Nutrition (2010) 64, 1235-1238; doi:10.1038/ejcn.2010.124; published online 4 August 2010