Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.
Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.
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DOI：
10.1080/2162402x.2015.1052934
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发表时间：
2015-12
期刊：
影响因子：
7.2
通讯作者：
Sitkovsky M
中科院分区：
文献类型：
--
作者：
Hatfield SM;Sitkovsky M
肿瘤的氧合削弱了缺氧和细胞外富含腺苷的微环境中 A2A 腺苷受体的肿瘤保护性免疫抑制信号传导。这反过来又释放了原本受到抑制的肿瘤反应性 T 细胞和自然杀伤 (NK) 细胞。因此，肿瘤氧合成为一种具有潜在治疗价值的新型检查点抑制剂，但只能与癌症免疫疗法结合使用。
Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.