Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs.
Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs.
复制标题
心血管病理中细胞焦亡的调节：非编码 RNA 的作用
DOI：
10.1016/j.omtn.2021.05.016
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发表时间：
2021-09-03
期刊：
影响因子：
--
通讯作者：
Shao K
中科院分区：
文献类型：
--
作者：
Gao J;Chen X;Wei P;Wang Y;Li P;Shao K
心血管疾病是危害人类生命的重要疾病之一。心血管疾病的发病机制是复杂的。与传统的细胞凋亡和坏死不同，细胞凋亡的特征是细胞肿胀直至膜破裂，导致细胞内容物的释放和强烈的炎症反应的激活。近年来的研究表明炎症和细胞凋亡在心血管疾病的发展中起重要作用。非编码RNA（ncRNA）被认为是诊断和治疗包括心血管疾病在内的各种疾病的有前途的生物标志物和潜在的治疗靶点。越来越多的证据表明，ncRNA可以通过参与细胞凋亡调控网络来介导细胞凋亡相关基因的转录或转录后调控。近年来，热固调节ncRNA在心血管疾病中的作用及其分子机制受到越来越多的关注。本文就ncRNAs，特别是microRNAs（miRNAs）、longncRNAs（lncRNAs）和circularRNAs（circRNAs）在CVD病理过程中对细胞凋亡的调控作用的研究进展进行综述。鉴定这些疾病相关的ncRNA对于了解心血管疾病的发病机制以及为其预防和治疗提供新的靶点和思路具有重要意义。心血管疾病是危害人类生命的重要疾病之一。焦亡和非编码RNA（ncRNA）在CVD的进展中起重要作用。鉴定靶向脓毒症的ncRNA对于了解心血管疾病的发病机制，为心血管疾病的防治提供新的靶点和思路具有重要意义。
Cardiovascular disease (CVD) is one of the most important diseases endangering human life. The pathogenesis of CVDs is complex. Pyroptosis, which differs from traditional apoptosis and necrosis, is characterized by cell swelling until membrane rupture, resulting in the release of cell contents and activation of a strong inflammatory response. Recent studies have revealed that inflammation and pyroptosis play important roles in the progression of CVDs. Noncoding RNAs (ncRNAs) are considered promising biomarkers and potential therapeutic targets for the diagnosis and treatment of various diseases, including CVDs. Growing evidence has revealed that ncRNAs can mediate the transcriptional or posttranscriptional regulation of pyroptosis-related genes by participating in the pyroptosis regulatory network. The role and molecular mechanism of pyroptosis-regulating ncRNAs in cardiovascular pathologies are attracting increasing attention. Here, we summarize research progress on pyroptosis and the role of ncRNAs, particularly microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of pyroptosis in CVD pathologies. Identifying these disease-related ncRNAs is important for understanding the pathogenesis of CVDs and providing new targets and ideas for their prevention and treatment. Cardiovascular disease (CVD) is one of the most important diseases endangering human life. Pyroptosis and noncoding RNAs (ncRNAs) play important roles in the progression of CVDs. Identifying pyroptosis-targeted ncRNAs is important for understanding the pathogenesis of CVDs and providing new targets and ideas for the prevention and treatment of CVDs.
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