ADVERSE REACTIONS IN HEALTHY AND IMMUNOCOMPROMISED CHILDREN UNDER 6 YEARS OF AGE VACCINATED WITH THE DANISH BCG VACCINE, STRAIN COPENHAGEN 1331 - IMPLICATIONS FOR THE VACCINATION POLICY IN SWEDEN
ADVERSE REACTIONS IN HEALTHY AND IMMUNOCOMPROMISED CHILDREN UNDER 6 YEARS OF AGE VACCINATED WITH THE DANISH BCG VACCINE, STRAIN COPENHAGEN 1331 - IMPLICATIONS FOR THE VACCINATION POLICY IN SWEDEN
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DOI：
10.1111/j.1651-2227.1993.tb12808.x
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发表时间：
1993-12-01
期刊：
影响因子：
3.8
通讯作者：
WIHOLM, BE
中科院分区：
文献类型：
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作者：
ROMANUS, V;FASTH, A;WIHOLM, BE
对1979年至1991年期间在瑞典接种丹麦卡介苗哥本哈根1331株疫苗的139000名6岁以下儿童中报告的不良反应进行回顾性分析，结果显示每1000名接种儿童中有1.9例发生不良反应。区域性淋巴结肿大和/或淋巴结肿大最常见，报告率为1.4/1000。严重的，传播性的，卡介苗感染的发展，在四个婴儿接种疫苗。其中三名婴儿患有严重的联合免疫缺陷综合征，在接种疫苗时未确诊。与瑞典所有新生儿（每100 000名新生儿中有1名）相比，接种BCG疫苗的人群（出生后一年内接种疫苗的婴儿中每100 000名中有4名）中严重联合免疫缺陷综合征的发病率较高。7名未接种卡介苗的婴儿出现症状的平均年龄为2.4个月，而4名接种卡介苗的婴儿为1.3个月，而未接种疫苗的婴儿平均年龄为7.6个月，而接种卡介苗的婴儿平均年龄为5.3个月。建议对结核病高危婴儿选择性接种卡介苗应推迟至6个月龄，以降低新生儿患免疫缺陷综合征的风险。
A retrospective analysis of the adverse reactions reported between 1979 and 1991, in the 139 000 children under six years of age vaccinated in Sweden with the Danish BCG vaccine, strain Copenhagen 1331, showed an incidence of 1.9 per 1000 vaccinated children. Regional lymphoglandular swellings and/or abscesses were most commonly reported in 1.4 per 1000. Serious, disseminated, BCG infections developed in four infants vaccinated neonatally. Three of the infants suffered from severe, combined, immunodeficiency syndrome, undiagnosed at the time of vaccination. The incidence of severe, combined, immunodeficiency syndrome was higher in the BCG-vaccinated population (4 per 100 000 infants vaccinated within a year of their births), compared with all newborns in Sweden (1 per 100 000). The mean age at the onset of symptoms was 2.4 months for the seven non-BCG-vaccinated infants versus 1.3 months for the four BCG-vaccinated ones, while the immunodeficiency syndrome was diagnosed at an average age of 7.6 months in those who were not vaccinated versus 5.3 months in those BCG-vaccinated. It is recommended that the selective BCG vaccination bf infants at high risk of exposure to tuberculosis should be postponed to six months of age to reduce the risk of inoculating infants suffering from immunodeficiency syndromes.