Control of gene expression by translational recoding.
Control of gene expression by translational recoding.
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DOI：
10.1016/b978-0-12-386497-0.00004-9
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发表时间：
2012
影响因子：
--
通讯作者：
Dinman JD
中科院分区：
文献类型：
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作者：
Dinman JD
像所有规则一样，即使是遗传密码也有例外：这些通常被归类为“翻译重新编码”。几乎每一种可能的重新编码模式都有记载，包括重新定义翻译阅读框架和密码子分配的信号。虽然首先在病毒中描述，但越来越清楚的是，编程延长核糖体以移动翻译阅读框架的序列被生物体广泛用于生命的所有领域，从而扩展了基因组的编码能力和在转录后水平调控基因表达的模式。程序性核糖体移码和终止密码子重排的出现为治疗许多先天性代谢缺陷开辟了新的途径。这些发现对人类健康的影响才刚刚开始显现。
Like all rules, even the genetic code has exceptions: these are generically classified as “translational recoding.” Almost every conceivable mode of recoding has been documented, including signals that redefine translational reading frame and codon assignation. While first described in viruses, it is becoming clear that sequences that program elongating ribosomes to shift translational reading frame are widely used by organisms in all domains of life, thus expanding both the coding capacity of genomes and the modes through which gene expression can be regulated at the posttranscriptional level. Instances of programmed ribosomal frameshifting and stop codon reassignment are opening up new avenues for treatment of numerous inborn errors of metabolism. The implications of these findings on human health are only beginning to emerge.