Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity
Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity
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DOI：
10.1016/j.phytol.2010.02.006
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发表时间：
2010-06
影响因子：
1.7
通讯作者：
H. K. Wabo;H. Kikuchi;Yasuhiro Katou;P. Tane;Y. Oshima
中科院分区：
文献类型：
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作者：
H. K. Wabo;H. Kikuchi;Yasuhiro Katou;P. Tane;Y. Oshima
从丁酸Pentadesma butyracea的根中分离得到新的杂山酮3,4-二氢-8,10,12-三羟基-2,2-二甲基吡喃[2,3-b]杂山酮-11(2H)- 1或丁杂山酮E(1)，以及已知的化合物30-表黄素(2)、1,7-二羟基杂山酮(3)和1,5-二羟基杂山酮(4)。通过光谱学方法和与已发表数据的比较，对它们的结构进行了分析。研究了它们对果蝇S2细胞和两种人类癌细胞系THP-1（白血病）和HCT116（结肠癌）的抗增殖活性。化合物1和2分别对果蝇S2细胞和HCT116细胞系表现出中等的抗增殖活性。化合物2对果蝇S2细胞有活性。
A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.