Role of the prefrontal cortex in the foreperiod effect: TMS evidence for dual mechanisms in temporal preparation
Role of the prefrontal cortex in the foreperiod effect: TMS evidence for dual mechanisms in temporal preparation
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DOI：
10.1093/cercor/bhj163
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发表时间：
2007-02-01
期刊：
影响因子：
3.7
通讯作者：
Walsh, Vincent
中科院分区：
文献类型：
--
作者：
Vallesi, Antonino;Shallice, Tim;Walsh, Vincent
右背外侧前额叶皮层（rDLPFC）参与外显时间加工的研究已有很多文献。相反，这个区域在内隐时间处理中的作用（例如，但对它的影响，人们还知之甚少。FP效应通常在一系列可变FP随机且等概率地发生时观察到，由反应时间（RT）随FP增加而减少组成。此外，在这样的范例中，RT作为先前FP的函数而增加（即，连续效应）。rDLPFC病变的患者未显示典型的FP效应。本研究旨在使用经颅磁刺激（TMS）在健康成年人中复制这些结果，并进一步研究FP效应降低后是否会发生任何顺序效应的变化。2个实验（分别与简单和选择RT任务）的结果表明，FP效应在rDLPFC经颅磁刺激后显着降低，而左对侧部位和右角回刺激后没有观察到效果。相反，序贯效应不受TMS的影响。一个双过程模型的FP现象提出了解释之间的分离发现的2个效果。
The involvement of right dorsolateral prefrontal cortex (rDLPFC) in explicit temporal processing is well documented. Conversely, the role of this area in implicit temporal processing (e.g., foreperiod [FP] effect) is still poorly understood. The FP effect, usually observed when a range of variable FPs occur randomly and equiprobably, consists of reaction times (RTs) decreasing as the FP increases. Moreover, in such paradigms, RTs increase as a function of the preceding FP (i.e., sequential effects). Patients with lesions of the rDLPFC do not show the typical FP effect. The present study aimed to replicate these results in healthy adults using transcranial magnetic stimulation (TMS) and to further investigate whether any change of sequential effects follows a reduction of the FP effect. The results of 2 experiments (with simple and choice RT tasks, respectively) indicate that the FP effect was significantly reduced after TMS over the rDLPFC, whereas no effect was observed after stimulation of a left contralateral site and the right angular gyrus. Conversely, sequential effects were not influenced by TMS. A dual-process model of the FP phenomena is proposed to interpret the dissociation found between the 2 effects.