Incidence and risk factors for newly acquired hepatitis C virus infection among Aboriginal versus non-Aboriginal Canadians in six regions, 1999–2004
Incidence and risk factors for newly acquired hepatitis C virus infection among Aboriginal versus non-Aboriginal Canadians in six regions, 1999–2004
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1999-2004 年六个地区原住民与非原住民加拿大人新感染丙型肝炎病毒的发病率和危险因素
DOI：
10.1007/s10096-007-0267-7
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发表时间：
2007
影响因子：
4.5
通讯作者：
Enhanced Hepatitis Strain Surveillance System
中科院分区：
文献类型：
--
作者：
H.;J. Wu;T. Wong;A. Andonov;Q. Li;K. Dinner;T. Donaldson;S. Paton;Enhanced Hepatitis Strain Surveillance System
本研究的目的是比较丙型肝炎病毒（HCV）的发病率和最近的传播模式在土著和非土著加拿大人。分析了加拿大6个司法管辖区向增强型肝炎病毒监测系统报告的新获得性HCV感染病例（≥15岁患者）。使用标准化问卷收集关于人口统计学和临床特征以及HCV感染的危险因素的信息。单变量分析显示，土著患者比非土著患者更有可能报告注射吸毒（77.1% vs. 64.0%; p < 0.05），女性（54.6% vs. 37.6%; p < 0.05）、报告高危性行为（48.6% vs. 34.1%，p < 0.05）和报告吸毒（45.7% vs. 32.7%，p < 0.05）。土著患者的中位年龄明显小于非土著患者（31岁[范围，15-71] vs. 34岁[范围，15-81]; p < 0.05）。每100，000名15岁及以上人群中HCV感染的总发病率在土著人群中为18.9（95%置信区间[CI] 15.5-23.1），在非土著人群中为2.8（95%CI 2.6-3.1）。Poisson回归分析显示，加拿大土著居民比非土著居民更容易患急性丙型肝炎（校正率比5.8，95%CI 4.7-7.3）。需要制定适当且有效的公共卫生战略，其中包括与原住民社区合作规划和实施的预防计划。
The purpose of this study was to compare hepatitis C virus (HCV) incidence and recent patterns of transmission within Aboriginal and non-Aboriginal Canadians. Cases of newly acquired HCV infection (in patients ≥15 years) reported to the Enhanced Hepatitis Strain Surveillance System from six jurisdictions in Canada were analyzed. Information on demographic and clinical characteristics as well as risk factors for HCV infection was collected using standardized questionnaires. Univariate analysis showed Aboriginal patients to be significantly more likely than non-Aboriginal patients to report injection drug use (77.1% vs. 64.0%; p < 0.05), to be female (54.6% vs. 37.6%; p < 0.05), to report high-risk sexual behaviors (48.6% vs. 34.1%, p < 0.05), and to report drug snorting (45.7% vs. 32.7%, p < 0.05). The median age of Aboriginal patients was significantly younger than that of non-Aboriginal patients (31 years [range, 15–71] vs. 34 years [range, 15–81]; p < 0.05). The overall incidence of HCV infection per 100,000 people aged 15 years and older was 18.9 (95% confidence interval [CI] 15.5–23.1) in Aboriginal people and 2.8 (95%CI 2.6–3.1) in non-Aboriginal people. Poisson regression analysis revealed that Aboriginal Canadians were more likely than non-Aboriginal Canadians to develop acute hepatitis C (adjusted rate ratio 5.8, 95%CI 4.7–7.3). An appropriate and effective public health strategy that includes planned and implemented prevention programs in partnership with the Aboriginal community is needed.