An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media
An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media
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DOI：
10.1080/10717540500313034
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发表时间：
2006-01-01
期刊：
影响因子：
6
通讯作者：
Stupar, M
中科院分区：
文献类型：
--
作者：
Stanojevic, M;Krusic, MK;Stupar, M
研究了丙烯酰胺和衣康酸自由基共聚制备的水凝胶的组成和交联度，以寻找具有令人满意的溶胀和药物释放性能的材料。通过测量对乙酰氨基酚作为模型药物在不同 pH 值的水介质中的溶胀行为和体外释放来表征样品。采用二因素三水平实验设计和响应面法对研究因素的影响进行统计评估。
The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors.