Relationship Between White Matter Hyperintensities Penumbra and Cavity Formation.
Relationship Between White Matter Hyperintensities Penumbra and Cavity Formation.
复制标题
白质高信号半影与空洞形成之间的关系
DOI：
10.12659/msm.896324
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发表时间：
2016-01-05
期刊：
影响因子：
--
通讯作者：
Hu W
中科院分区：
文献类型：
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作者：
Zhang X;Ding L;Yang L;Qin W;Li Y;Li S;Hu W
在白色高信号（WMH）边缘检测到背景半影。我们研究的目的是探讨WMH边缘和远离边缘的急性梗死之间空洞形成是否不同。材料/方法96例直径≤25 mm的急性腔隙性脑梗死患者。将与WMH（轴向T2或冠状FLAIR）接触或重叠的梗死受试者定义为边缘组（WMH边缘）。那些在WMH边缘之外的人是非边缘组。记录血管危险因素、临床数据、基线梗死面积、梗死部位和WMH严重程度（Fazekas量表）。通过MR随访成像确定空洞形成。还调查了空洞形成的风险因素。结果边缘组37例（38.5%），无边缘组59例（61.5%），随访影像学检查有空洞形成55例（57.3%）。边缘组的受试者比非边缘组的受试者有更高的患龋风险（78.4% vs. 44.1%，p<0.05）。在单因素分析中，有空洞形成的受试者梗死面积较大，梗死部位多位于皮质下白色物质。血管危险因素、临床数据和WMH在有空洞形成的受试者和没有空洞形成的受试者之间没有差异。Logistic回归分析显示，DWI梗死面积和边缘组是空洞形成的独立危险因素。结论位于WMH边缘的腔隙性梗死更易形成空洞，提示WMH半暗带影响空洞的形成。
Background Penumbra has been detected on the edge of white matter hyperintensities (WMH). The aim of our study was to investigate whether cavity formation is different between acute infarcts on the edge of WMH and those away from the edge. Material/Methods Ninety-six subjects with acute lacunar infarct ≤25 mm in diameter were recruited. Subjects with infarct contacting or overlapping with WMH (on axial T2 or coronal FLAIR) were defined as the Edge Group (on the edge of the WMH). Those outside the edge of the WMH were the Non-edge Group. Vascular risk factors, clinical data, baseline infarct size, infarct sites, and severity of WMH (by Fazekas scale) were recorded. Cavity formation was identified by MR follow-up imaging. Risk factors for cavity formation were also investigated. Results There were 37 (38.5%) subjects in the Edge Group and 59 (61.5%) in the Non-edge Group; 55 (57.3%) subjects had cavity formation in follow-up imaging. Subjects in the Edge Group had higher risk of developing cavities than those in the Non-edge Group (78.4% vs. 44.1%, p<0.05). In univariate analysis, subjects with cavity formation had larger infarct size and their infarcts were more often located in subcortical white matter. Vascular risk factors, clinical data, and WMH did not differ between subjects with cavity formation and those without. In logistic regression analysis, DWI infarct size and being in the Edge Group were independent risk factors for cavity formation. Conclusions Lacunar infarcts on the edge of WMH are more likely to develop cavities, suggesting that WMH penumbra affects cavity formation.