AMPHETAMINE AND THERMOREGULATION - STUDIES IN UNRESTRAINED AND CURARIZED RAT
AMPHETAMINE AND THERMOREGULATION - STUDIES IN UNRESTRAINED AND CURARIZED RAT
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DOI：
10.1007/bf00499429
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发表时间：
1974-01-01
影响因子：
3.6
通讯作者：
WASER, PG
中科院分区：
文献类型：
--
作者：
BORBELY, AA;BAUMANN, IR;WASER, PG
我们研究了 (+)-安非他明对不受约束和箭毒注射的大鼠体温的影响。在环境温度为 30°C 的不受约束的动物中，安非他明具有剂量依赖性的高温作用，而在环境温度为 7°C 的动物中，安非他明会降低体温。箭毒注射后的大鼠体温也明显升高。 C1 水平脊髓横断后；和有髓的老鼠。用α-肾上腺素能阻断剂阿扎佩汀进行预处理可减弱箭毒大鼠的安非他明高热反应，但增强未受限制大鼠的高热反应。用β-肾上腺素能阻断剂普萘洛尔进行预处理消除了箭毒大鼠的安非他明高热，但不影响不受约束的动物的反应。在垂体切除的动物中，即使在高环境温度下，安非他明也具有降低体温的作用。结论是，安非他明对外周β受体的作用具有高温效应，但自由活动动物的热反应还涉及其他机制。
We investigated the effect of (+)-amphetamine on body temperature in the unrestrained and curarized rat. In the unrestrained animal kept at an ambient temperature of 30°C amphetamine had a dose-dependent hyperthermic action, whereas in animals kept at 7°C it decreased body temperature. An increase in body temperature was evident also in the curarized rat; after spinal cord transection at the level of C1; and in the pithed rat. Pretreatment with the alpha-adrenergic blocking agent azapetine attenuated amphetamine-hyperthermia in the curarized rat, but enhanced the hyperthermic response in the unrestrained rat. Pretreatment with the beta-adrenergic blocking agent propranolol abolished amphetamine-hyperthermia in the curarized rat, but did not affect the response in the unrestrained animal. In the hypophysectomized animal amphetamine had a hypothermic effect even at high ambient temperatures. It is concluded that the action of amphetamine on peripheral beta-receptors has a hyperthermic effect, but that additional mechanisms are involved in the thermal response of the freely moving animal.