Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure.
Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure.
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非职业暴露的美国人群和疑似暴露人群中挥发性有机化合物的血液浓度。
DOI：
10.1093/clinchem/40.7.1401
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发表时间：
1994
影响因子：
9.3
通讯作者：
J. Wooten
中科院分区：
文献类型：
--
作者：
D. Ashley;M. Bonin;F. Cardinali;J. McCraw;J. Wooten
在工业化国家，暴露于某些挥发性有机化合物（VOC）是常见的。我们建立了一种测定10 mL全血中32种低浓度VOCs的方法。我们使用这种方法来确定这些化合物的内部剂量在600或更多的人在美国谁参加了第三次全国健康和营养检查调查。根据我们的研究结果，我们建立了美国一般人群中这些VOC的参考范围。我们发现可检测浓度的1，1，1-三氯乙烷，1，4-二氯苯，2-丁酮，丙酮，苯，氯仿，三氯甲烷，间，对二甲苯，苯乙烯，四氯乙烷，甲苯在大多数非职业暴露人员的血液样本。VOC评估的准确性取决于研究人员对低浓度VOC进行灵敏和可重复测量的能力，以及消除所有干扰和污染源的能力。
Exposure to certain volatile organic compounds (VOCs) commonly occurs in industrialized countries. We developed a method for measuring 32 VOCs in 10 mL of whole blood at low concentration. We used this method to determine the internal dose of these compounds in 600 or more people in the US who participated in the Third National Health and Nutrition Examination Survey. From our study results, we established a reference range for these VOCs in the general population of the US. We found detectable concentrations of 1,1,1-trichloroethane, 1,4-dichlorobenzene, 2-butanone, acetone, benzene, chloroform, ethylbenzene, m,p-xylene, styrene, tetrachloroethane, and toluene in most of the blood samples of nonoccupationally exposed persons. The accuracy of VOC evaluations depends on the ability of investigators to make sensitive and reproducible measurements of low concentrations of VOCs and to eliminate all sources of interference and contamination.