Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons.
Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons.
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DOI：
10.1126/science.7541558
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发表时间：
1995-07
期刊：
影响因子：
56.9
通讯作者：
D. Sretavan;E. Puré;M. Siegel;L. Reichardt
中科院分区：
文献类型：
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作者：
D. Sretavan;E. Puré;M. Siegel;L. Reichardt
从眼睛生长的小鼠视网膜神经节细胞轴突在视交叉的未来位置遇到胚胎神经元。在体内用单克隆抗体和补体消融这些交叉神经元后，视网膜轴突没有越过中线，并在进入交叉区的大约位置停滞。因此，在小鼠中，视网膜神经节细胞轴突形成视交叉需要位于未来交叉位置的早期生成神经元的存在。
Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.