Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma
Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma
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DOI：
10.21873/anticanres.11366
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发表时间：
2017-02-01
影响因子：
2
通讯作者：
Lai, Jin-Ping
中科院分区：
文献类型：
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作者：
Grace, Shane A.;Meeks, Marshall W.;Lai, Jin-Ping
背景：肥胖是胰腺导管腺癌（PDAC）发生的一个既定危险因素。然而，肥胖增加如何增加PDAC风险的病理生理学尚未完全阐明。脂肪甘油三酯脂肪酶（ATGL）是一种分解代谢甘油三酯水解的脂肪酶，与乳腺癌的发生有关。我们假设，超重患者PDAC将表现出较高的肿瘤ATGL表达与非超重患者PDAC.Materials和方法：ATGL表达的免疫组化分析进行PDAC组织从44例维普莱程序或远端胰腺切除术后。分析ATGL表达与临床病理特征的相关性。结果如下：共有23/44例（52.2%）PDAC显示低水平ATGL免疫反应性，而21/44例（47.8%）显示高水平，在超过50%的肿瘤细胞中显示中等至强阳性ATGL免疫反应性。卡方检验显示ATGL高表达与BMI > 25 kg/m2（chi（2）=5.74，p=0.017）和肿瘤间质增加（chi（2）=19.14，p < 0.001）之间存在统计学显著相关性。卡方检验未能揭示一个统计学上显着的关联时，比较ATGL表达淋巴结转移，组织学分级，肿瘤大小，患者年龄，患者性别和存在的脂肪invasion.Conclusion：我们的研究结果表明，ATGL表达增加与PDAC患者的肥胖和间质增殖增加，使其成为一个可能的关键蛋白质在肥胖如何增加PDAC的风险。
Background: Obesity is an established risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). However, the pathophysiology of how increased adiposity increases the risk for PDAC has not been fully elucidated. Adipose triglyceride lipase (ATGL) is a lipase that catabolizes triglyceride hydrolysis and has been implicated in the development of breast cancer. We hypothesized that overweight patients with PDAC would demonstrate higher tumor ATGL expression compared to non-overweight patients with PDAC.Materials and Methods: Immunohistochemical analysis for ATGL expression was performed on PDAC tissues from 44 patients after Whipple procedure or distal pancreatectomy. Correlation of ATGL expression with clinicopathological features was evaluated. Results: A total of 23/44 (52.2%) PDACs showed low level ATGL immunoreactivity, while 21/44 (47.8%) showed a high level, with moderate to strong positive ATGL immunoreactivity in more than 50% of the tumor cells. Chisquared testing revealed a statistically significant association between high ATGL expression and both BMI > 25 kg/m(2) (chi(2)=5.74, p=0.017) and increased tumor stroma (chi(2)=19.14, p < 0.001). Chi-squared testing failed to reveal a statistically significant association when comparing ATGL expression by lymph node metastasis, histological grade, tumor size, patient age, patient sex and presence of fat invasion.Conclusion: Our results suggest that increased ATGL expression is associated with increased adiposity and stromal proliferation in patients with PDAC, making it a possible key protein in how obesity increases the risk of PDAC.