Plastic microfluidic devices modified with polyelectrolyte multilayers
Plastic microfluidic devices modified with polyelectrolyte multilayers
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DOI：
10.1021/ac000548o
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发表时间：
2000-10-15
影响因子：
7.4
通讯作者：
Locascio, LE
中科院分区：
文献类型：
--
作者：
Barker, SLR;Tarlov, MJ;Locascio, LE
聚合物表面化学的控制是塑料微流控装置发展的一个重要方面。当商用塑料基板用于制造微通道时，塑料与塑料之间EOF迁移率的差异可能非常高。因此，我们使用聚电解质多层膜（PEMs）来改变塑料微通道的表面。通过在微通道表面交替涂覆聚丙烯胺盐酸盐和聚苯乙烯磺酸盐，得到了微通道表面的最佳修饰。选择聚苯乙烯（PS）和聚对苯二甲酸乙酯（PETG）作为衬底材料，是因为这两种塑料材料的聚合物化学性质和通道的EOF有显著差异。利用XPS和EOF迁移率对表面改性的效果进行了评价。当用PEMs修饰PS和PETG制备的微通道时，它们表现出非常相似的电渗透迁移率。PEMs易于制造，并提供了一种控制电流方向和通道内电渗透迁移率的手段。pem涂层微通道具有优异的润湿性，允许通道易于填充。此外，PEMs产生可重复的结果，并且足够坚固，可以承受长期存储。
Control of the polymer surface chemistry is a crucial aspect of development of plastic microfluidic devices. When commercially available plastic substrates are used to fabricate microchannels, differences in the EOF mobility from plastic to plastic can be very high. Therefore, we have used polyelectrolyte multilayers (PEMs) to alter the surface of microchannels fabricated in plastics. Optimal modification of the microchannel surfaces was obtained by coating the channels with alternating layers of poly(allylamine hydrochloride) and poly(styrene sulfonate). Polystyrene (PS) and poly(ethylene terephthalate) glycol (PETG) were chosen las substrate materials because of the significant differences in the polymer chemistries and in the EOF of channels fabricated in these two plastic materials. The efficacy of the surface modification has been evaluated using XPS and by measuring the EOF mobility. When microchannels prepared in both PS and PETG are modified with PEMs, they demonstrate very similar electroosmotic mobilities. The PEMs are easily fabricated and provide a means for controlling the now direction and the electroosmotic mobility in the channels. The PEM-coated microchannels have excellent wettability, allowing facile filling of the channels. In addition, the PEMs produce reproducible results and are robust enough to withstand long-term storage.