Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs
Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs
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DOI：
10.1111/j.1600-051x.2010.01539.x
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发表时间：
2010-04-01
影响因子：
6.7
通讯作者：
Noguchi, Kazuyuki
中科院分区：
文献类型：
--
作者：
Shirakata, Yoshinori;Taniyama, Katsuyoshi;Noguchi, Kazuyuki
目的本研究的目的是评估碱性成纤维细胞生长因子（bFGF）候选治疗对犬双壁骨内缺损牙周愈合的影响。材料和方法在4只比格犬双侧下颌第二和第四前磨牙的远中侧手术建立双壁骨内缺损（5 × 5 × 5 mm）。bFGF、釉质基质衍生物（EMD）和血小板衍生生长因子与β-磷酸三钙（PDGF/β-TCP）治疗和假手术（OFD）在每只动物的四个缺损之间旋转，EMD和PDGF/β-TCP作为基准对照。结果bFGF组（4.11 +/- 0.77 mm）的骨形成显著大于EMD组（3.32 +/-0.71 mm; p < 0.05）和OFD组（3.09 +/- 0.52 mm; p < 0.01）。EMD组（4.59 ± 1.19 mm）和PDGF/beta-TCP组（4.66 ± 0.7 mm）与OFD组（2.96 ± 0.69 mm; p < 0.01）相比，具有牙周韧带样组织的牙骨质再生明显更强。bFGF和PDGF/β-TCP组在任何histometric parameters.ConclusionsThe候选人bFGF治疗支持牙周再生与既定的基准：EMD和PDGF/β-TCP之间没有显着差异。
P>AimThe aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs.Materials and MethodsTwo-wall intrabony defects (5 x 5 x 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet-derived growth factor with beta-tricalcium phosphate (PDGF/beta-TCP) treatments, and sham-surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/beta-TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks.ResultsBone formation was significantly greater in the bFGF group (4.11 +/- 0.77 mm) than in the EMD (3.32 +/- 0.71 mm; p < 0.05) and OFD (3.09 +/- 0.52 mm; p < 0.01) groups. The EMD (4.59 +/- 1.19 mm) and PDGF/beta-TCP (4.66 +/- 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament-like tissue than the OFD group (2.96 +/- 0.69 mm; p < 0.01). No significant differences were observed between the bFGF and the PDGF/beta-TCP groups in any of the histometric parameters.ConclusionsThe candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/beta-TCP.