C2-Symmetrical Bipyridyldiols as Promising Enantioselective Catalysts in Nozaki-Hiyama Allylation
C2-Symmetrical Bipyridyldiols as Promising Enantioselective Catalysts in Nozaki-Hiyama Allylation
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DOI：
10.1002/adsc.201100023
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发表时间：
2011-08-01
影响因子：
5.4
通讯作者：
Chen, Chinpiao
中科院分区：
文献类型：
--
作者：
Huang, Xin-Ren;Pan, Xin-Hong;Chen, Chinpiao
合成了几种新的手性联吡啶二醇配体，可促进铬催化烯丙基卤化物对醛的对映选择性加成反应，EE 高达 99%。在氯化铬(III)和烯丙基氯存在下，使用配体 4 和 4a 进行的铬催化醛烯丙基化反应提供了最高的对映选择性。
Several new chiral bipyridyldiol ligands that promote the chromium-catalyzed enantioselective addition of allylic halides to aldehydes in up to 99% ee were synthesized. The chromium-catalyzed allylation of aldehydes using ligands 4 and 4a in the presence of chromium(III) chloride and allyl chloride provided the highest enantioselectivity.