RELATION OF THALAMIC CELL RESPONSE TO PERIPHERAL STIMULI VARIED OVER AN INTENSIVE CONTINUUM
RELATION OF THALAMIC CELL RESPONSE TO PERIPHERAL STIMULI VARIED OVER AN INTENSIVE CONTINUUM
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DOI：
10.1152/jn.1963.26.5.807
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发表时间：
1963-01-01
影响因子：
2.5
通讯作者：
WERNER, G
中科院分区：
文献类型：
--
作者：
MOUNTCASTLE, VB;POGGIO, GF;WERNER, G
在未麻醉的去传入头猴中，用单细胞分析法研究了腹基底核复合体中对肢体关节位置和旋转反应的神经元。这些细胞，其连接的外周传入，和介入的二级神经元形成一个系统，这是一个绝对的检测器的关节角度。神经反应已被测量的单位时间的脉冲，视为增量超过刺激前放电率，并建立测量的有效性。关节位置已通过精确的仪器控制改变，并沿着比率刻度测量，该比率刻度的零是每个细胞的兴奋角的边缘。丘脑细胞放电和关节位置之间的关系由以下形式的幂函数充分描述：R = KSn C，其中R =反应，K是比例常数，S =刺激，C是刺激前活动的常数。对于所研究的神经元群体，指数n平均约为0.7。这些发现与最近的心理-生理观察进行了比较。丘脑细胞的兴奋角总是单端的和单调的，在兴奋运动的最大程度上的最大放电率。这些和其他人对一阶联合传入的观察结果之间的差异已被解释为传入系统的突触中继的转化作用的迹象，并从它们在整合作用中的作用的角度进行了讨论。
Those neurons of the ventrobasal nuclear complex which are responsive to the position and rotation of the limbs at their joints were studied by the method of single unit analysis, in unanesthetized "de-afferented-head" monkeys. These cells, their linked peripheral afferents, and intervening second order neurons form a system which is an absolute detector of joint angle. Neural response has been measured in terms of impulses per unit time, treated as increment over the pre-stimulus discharge rate, and the validity of measurement established. Joint position has been varied by precise instrumental control, and measured along a ratio scale whose zero is the edge of the excitatory angle for each cell. The relation between thalamic cell discharge and joint position is adequately described by a power function of the form: R = KSn C, where R = response, K is a constant of proportionality, S = stimulus, and C is the constant for pre-stimulus activity. The exponent n averaged about 0.7 for the population of neurons studied. These findings have been compared with recent psycho-physical observations. The excitatory angles for thalamic cells are always single-ended and monotonic, with maximal discharge rates at the full extent of the exciting movement. The differences between these and the observations of others on the first order joint afferents have been interpreted as signs of the transforming action at the synaptic relays of an afferent system, and discussed from the point of view of their role in integrative action.