Matters of class: coming of age of class III and IV lanthipeptides.
Matters of class: coming of age of class III and IV lanthipeptides.
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DOI：
10.1039/d0cb00073f
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发表时间：
2020-08-01
影响因子：
4.1
通讯作者：
Süssmuth RD
中科院分区：
文献类型：
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作者：
Hegemann JD;Süssmuth RD
Lanthipeptides 属于核糖体合成和翻译后修饰肽 (RiPP) 超家族。尽管它们代表了已知最长的 RiPP 亚科之一，但它们最年轻的成员（III 类和 IV 类）直到最近才被描述。从那时起，大量的研究进一步加深了对其生物合成的理解。尽管 III 类和 IV 类加工酶的结构域结构相似，因此它们之间存在共同点，但也存在显着的差异，因此可以区分它们。在这篇简明的综述文章中，我们总结了有关这些羊毛脂肽的基本生物合成原理的已知信息，并讨论了未来研究的开放问题。在这篇综述中，我们对 III 类和 IV 类羊毛肽合成酶的已知生物合成原理进行了简要概述。
Lanthipeptides belong to the superfamily of ribosomally-synthesized and posttranslationally-modified peptides (RiPPs). Despite the fact that they represent one of the longest known RiPP subfamilies, their youngest members, classes III and IV, have only been described more recently. Since then, a plethora of studies furthered the understanding of their biosynthesis. While there are commonalities between classes III and IV due to the similar domain architectures of their processing enzymes, there are also striking differences that allow their discrimination. In this concise review article, we summarize what is known about the underlying biosynthetic principles of these lanthipeptides and discuss open questions for future research. In this review, we give a concise overview of the known biosynthetic princples of class III and IV lanthipeptide synthtases.